The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males

Not Applicable

Recruiting

• Conditions: Hypoxia, Altitude
• Interventions: Other: Exercise and environmental conditions

• Registration Number: NCT06204731
• Lead Sponsor: University School of Physical Education, Krakow, Poland

Brief Summary

* Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal damage, and mitochondrial energy production rate in young sedentary males.

* Applied objective: Development of practical training guidelines utilizing training in normobaric hypoxia conditions to enhance mechanisms related to oxygen transport, adaptive changes within the immune system, body's antioxidant capacity, gut permeability, substrate utilization efficiency, and mitochondrial function for coaches and athletes.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-02-01
• Status Verified: 2023-12
• Study First Submitted: 2023-12-11
• Study First Submitted QC: 2024-01-03
• Last Update Submitted: 2024-01-03
• Study First Posted: 2024-01-12
• Last Update Posted: 2024-01-12
• Primary Completion: 2026-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

• no known metabolic diseases, no contraindications to physical exercise and no history of high altitude sickness stated in interview. A medical examination (including ECG, blood and urine tests) is required.

Exclusion Criteria

• changes in diet during the experiment, smoking and abuse of alcohol and/or other stimulants.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
LHTL (live high - train low)	Exercise and environmental conditions	Training performed under normoxic conditions (223m), stay and sleep in normobaric hypoxic conditions (3000m) and thermoneutral conditions (21°C) and constant humidity (40%).
LLTL (live low - train low)	Exercise and environmental conditions	Training performed and stay and sleep in normoxic conditions (223m) and thermoneutral conditions (21°C) and constant humidity (40%).
LLTH (live low - train high)	Exercise and environmental conditions	Training performed under normobaric hypoxia conditions (3000m), stay and sleep in normoxic conditions (223m) and thermoneutral conditions (21°C) and constant humidity (40%). will stay and sleep in normoxic (223m), and train in normobaric hypoxia (3000m)

Primary Outcome Measures

Name	Time	Method
Blood analysis	7 days before training and 7- 10 days after the training. The training will last 4 weeks and will consist of 12 workouts.	Indicators of prooxidant-antioxidant imbalance, markers of inflammatory status, markers of muscle damage, markers of intestinal damage, HIF (hypoxia-inducible factor), EPO (erythropoietin), markers of mitochondrial metabolism, morphology (including reticulocytes).
Measurement of aerobic capacity (endurance)	7 days before training and 7-10 days after the training. Training will last 4 weeks.	Measurement of maximal oxygen uptake and determination of ventilatory thresholds (ergospirometry)
Measurement of anaerobic capacity	7 days before training and 7-10 days after the training. Training will last 4 weeks	Measurement of maximal anaerobic power (Wingate Anaerobic Test)
Somatic indices	7 days before training and 7-10 days after the training. Training will last 4 weeks.	Body composition analysis ( body height \[m\], body mass \[kg\], Quetelet II Index \[kg/m\^2\], lean body mass \[kg\], fat mass \[kg\], fat percentage \[%\] and total water content \[kg\]

Trial Locations

Locations (1)

University School of Physical Education in Cracow; 🇵🇱 Krakow, Poland