JPRN-UMIN000008808
Completed
N/A
Exploratory study for biomarkers to predict efficacy and toxicity to Sorafenib in patients with advanced hepatocellular carcinoma - Biomarker study of sorafenib
ConditionsHepatocellulara carcinoma
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Hepatocellulara carcinoma
- Sponsor
- ational Cancer Center Hospital
- Enrollment
- 100
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •1\. Ineligible for dynamic CT or MRI; 2\. Patients with cerebral metastasis; 3\. Pregnant and breastfeeding women or those who may possibly be pregnant; 4\. Patients with uncontrollable hypertension (BP\>170 mmHg under medication) or with thromboembolism, ischemic heart disease, unstable angina pectoris, heart failure, or cerebrovascular disorder; 5\. Patients with moderate or severe renal dysfunction (Ccr \< 30 mL/min) including those on dialysis; 6\. Patients with esophageal varices that may cause bleeding (those who had gastrointestinal bleeding in the past month); 7\. Patients under treatment with drugs affecting the activity of CYP3A4 or UGT1A9 (e.g., carbamazepine, rifampicin, St. John's wort, etc. ) or drugs that may affect the serum concentration of sorafenib; 8\. Patients with diseases related to human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS); or 9\. Patients judged as ineligible by the investigator in charge for other reasons
Outcomes
Primary Outcomes
Not specified
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