JPRN-UMIN000008808已完成未知
Exploratory study for biomarkers to predict efficacy and toxicity to Sorafenib in patients with advanced hepatocellular carcinoma - Biomarker study of sorafenib
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- ot applicable 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1. Ineligible for dynamic CT or MRI; 2. Patients with cerebral metastasis; 3. Pregnant and breastfeeding women or those who may possibly be pregnant; 4. Patients with uncontrollable hypertension (BP>170 mmHg under medication) or with thromboembolism, ischemic heart disease, unstable angina pectoris, heart failure, or cerebrovascular disorder; 5. Patients with moderate or severe renal dysfunction (Ccr < 30 mL/min) including those on dialysis; 6. Patients with esophageal varices that may cause bleeding (those who had gastrointestinal bleeding in the past month); 7. Patients under treatment with drugs affecting the activity of CYP3A4 or UGT1A9 (e.g., carbamazepine, rifampicin, St. John's wort, etc. ) or drugs that may affect the serum concentration of sorafenib; 8. Patients with diseases related to human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS); or 9. Patients judged as ineligible by the investigator in charge for other reasons
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