effect of administration of intrathecal Dexmedetomidine on the Spinal Cord Mori
Phase 3
Recruiting
- Conditions
- umbar disc herniation.Thoracic, thoracolumbar, and lumbosacral intervertebral disc disorders
- Registration Number
- IRCT20200127046282N1
- Lead Sponsor
- Vice chancellor for research, Shahid Beheshti University of Medical Sciences , Loghman Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
No history of taking anti-inflammatory drugs two weeks before surgery
Lack of AIDS and immunosuppressive diseases
Exclusion Criteria
GCS reduction for a reason other than stroke
Change in the type of surgery according to the surgeon's opinion
History of systemic diseases such as diabetes mellitus, renal failure and chronic pulmonary heart disease
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The level of Bax / Bcl-2¬ apoptotic factor in cerebrospinal fluid in dexmedetomidine and placebo group. Timepoint: After surgery and at the end of surgery. Method of measurement: Study of cerebrospinal fluid in dexmedetomidine and placebo group by ELISA.;Numering Rating Scale (NRS) Pain score in dexmedetomidine and placebo group. Timepoint: Before anesthesia and in recovery. Method of measurement: NRS scoring system.;The level of caspase-3 apoptotic factor in cerebrospinal fluid in dexmedetomidine and placebo group. Timepoint: After surgery and at the end of surgery. Method of measurement: Study of cerebrospinal fluid in dexmedetomidine and placebo group by ELISA.
- Secondary Outcome Measures
Name Time Method