Depression and Anxiety Reduction Treatment for Suicide
- Conditions
- DepressionAnxietySuicide
- Interventions
- Behavioral: Psychoeducation and Cognitive Bias Modification
- Registration Number
- NCT01941862
- Lead Sponsor
- Florida State University
- Brief Summary
The purpose of this study is to test the effectiveness and usability of multiple computer-based treatments for mood and anxiety relevant risk factors. The target of the treatment is related to cognitive stress, which has been shown to be associated with a variety of negative mental health outcomes such as Post-Traumatic Stress Disorder, suicidal ideation, and substance use disorders.
- Detailed Description
DARTS is a newly developed computerized treatment targeting specific risk factors associated with suicide, mood, and anxiety symptoms. Eligible individuals will be randomized to one of several conditions. In all conditions, participants will complete various self-report questionnaires and a neurophysiology assessment that involves an EEG. Some participants will also be asked to complete four additional EEG assessments. In addition, all participants will be asked to complete a 1, 3, and 6-month follow-up appointment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 300
- At or above community sample mean on ASI-3
- At or above community sample mean on INQ-R
- English speakers
- 18 years of age or older
- Significant medical illness
- Current substance dependence
- Current or past psychotic-spectrum disorders
- Uncontrolled bipolar disorder
- Serious suicidal intent that warranted immediate treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Combined Risk Reduction Psychoeducation and Cognitive Bias Modification The combined intervention will involve all of the interventions in the anxiety and mood risk reduction conditions and thus will not be matched for length. Anxiety Risk Reduction Psychoeducation and Cognitive Bias Modification The anxiety risk reduction condition will be a combination of psychoeducation plus Cognitive Bias Modification (CBM-I) for anxiety sensitivity (AS). The psychoeducational component will focus on the nature of stress and its effect on the body. Interoceptive exposure (IE) exercises, designed to correct the conditioned fear to these bodily sensations, will be explained and practiced. Mood Risk Reduction Psychoeducation and Cognitive Bias Modification The mood risk reduction condition will be a combination of psychoeducation plus Cognitive Bias Modification (CBM-I) for perceived burdensomeness and thwarted belongingness. The psychoeducational component will focus on dispelling myths related to burdensomeness and belongingness and describe their role in the development of mood symptoms.
- Primary Outcome Measures
Name Time Method Interpersonal Needs Questionnaire (INQ) Month 6 follow-up The INQ is a 15-item self-report measure of the constructs of thwarted belongingness and perceived burdensomeness as defined by the Interpersonal Theory of Suicide. Van Orden et al. report high internal consistency coefficients for the thwarted belongingness (α=.85) and perceived burdensomeness subscales (α=.89). In support of construct validity, both subscales were found to prospectively predict suicidal ideation.
- Secondary Outcome Measures
Name Time Method Anxiety Sensitivity Index-3 (ASI-3) Month 6 follow-up The ASI-3 is an 18-item self-report measure of anxiety sensitivity (AS). This scale was developed to provide a more stable measure of the three most widely recognized AS subfactors (cognitive, social and physical concerns) than the original ASI provides. Each subfactor is represented by six items. The measure has shown good psychometric properties.
Trial Locations
- Locations (1)
Florida State University
🇺🇸Tallahassee, Florida, United States