EUCTR2018-000059-42-FR
Active, not recruiting
Phase 1
Comparison of short infusion versus prolonged infusion of ceftolozane-tazobactam among patients with ventilator associated-pneumonia to Pseudomonas aeruginosa in intensive care units - CEFTOREA
CHU DE TOULOUSE0 sites60 target enrollmentApril 9, 2018
DrugsZERBAXA
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- CHU DE TOULOUSE
- Enrollment
- 60
- Status
- Active, not recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age \= 18 years
- •patients with ventilator associated\-pneumonia to Pseudomonas aeruginosa
- •patients hospitalized in intensive care units
- •Pseudomonas aeruginosa susceptible to ceftolozane\-tazobactam
- •SAPS II (Simplified Acute. Physiological Score II) \> 20
- •Expected duration of survival \> 7 days
- •Informed consent of the patient or, failing that, the patient’s close or trustworthy person
- •Affiliated to a social security scheme or equivalent
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
Exclusion Criteria
- •history of allergy to one of the two molecules
- •history of allergy to betalactamines
- •Strain Isolated resistant to Ceftolozane\-Tazobactam combination
- •Renal insufficiency with a glomerular filtration rate evaluated by CKD\-EPI \< 50 ml/min
- •Patient on dialysis or under continuous hemodiafiltration
- •Pregnant or nursing women
- •Patient benefiting from a system of legal protection for adults
Outcomes
Primary Outcomes
Not specified
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