Perioperative Rehabilitation Therapy in Patients Undergoing Liver Transplantation: a Clinical Multicenter Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 750
- 主要终点
- 2-year overall survival
研究概览
简要总结
Patients undergoing liver transplantation frequently experience a reduction in skeletal muscle mass, malnutrition, and decreased levels of physical activity. These complications can adversely affect early postoperative recovery and the therapeutic effect of the transplant. This clinical study aims to investigate the effects of nutritional supplementation and rehabilitation therapy on sarcopenia associated with liver transplantation in adults. The goal is to establish a comprehensive perioperative intervention strategy to reduce the incidence of postoperative sarcopenia and improve transplantation outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 70 years.
- •Patients with end-stage liver disease who meet the criteria for liver transplantation (for liver cancer cases, only recipients meeting specific standards are included).
- •Complete clinical information, including documented pre-transplant muscle status (e.g., preoperative CT scans and handgrip strength tests).
- •High compliance with treatment, fully capable of independent action or having at least one assistant.
- •No contraindications to the planned interventions.
排除标准
- •Presence of musculoskeletal disorders before transplantation, such as myositis, idiopathic muscle atrophy, or history of hip surgery within the past three months.
- •Coexisting severe cardiovascular or cerebrovascular diseases, infectious diseases, or epilepsy.
- •Liver transplantation due to autoimmune liver disease or drug-induced liver failure.
- •Re-transplantation, multi-organ transplantation, living donor liver transplantation, split liver transplantation, or pediatric liver transplantation.
- •ABO-incompatible liver transplantation.
- •Incomplete clinical information.
- •Difficulty in follow-up.
结局指标
主要结局
2-year overall survival
时间窗: From enrollment to the end of follow-up at 2 years
At the 2-year mark, record the survival status of each patient (alive or deceased).
次要结局
- Muscle mass(From enrollment to the end of treatment at 6 months)
研究者
Xiao Xu
Professor
Zhejiang University