Functional and biochemical assessment of liver regeneration after major hepatectomy

Completed

• Conditions: bile duct tumor; colorectal liver metastsasis; Liver tumor; 10019815

• Registration Number: NL-OMON46514
• Lead Sponsor: Chirurgie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 33

Inclusion Criteria

Major liver resection (3 or more Couinaud segments)
Written informed consent
>= 18 years old

Exclusion Criteria

Serum bilirubine > 50 µmol/L
'Two-stage' procedures
ALPPS procedure
Allergy for mebrofenin
Pregnant

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Correlations between the changes in liver function (as measured with<br /><br>hepatobiliary scintigraphy) at day of admission versus postoperative day 5 and<br /><br>the concomitant changes in circulating regeneration biomarkers</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Variability of liver function whithin a patient.<br /><br>Correlation between postoperative changes in liver stiffness and changes in<br /><br>liver function (as measured with hepatobiliary scintigraphy) at day of<br /><br>admission versus postoperative day 5</p><br>