Early detection of ovarian cancer and response prediction: TEP and ctDNA study.

Completed

Conditions: ovarian tumor
ovarium cancer
10027656

Registration Number: NL-OMON50170

Lead Sponsor: Catharina-ziekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

Patients who are suspected of having ovarian cancer, patients who are diagnosed
with ovarian cancer, and patients with ovarian cysts of which it is unknown
whether it is benign or malignant and who receive either surgery with
definitive pathology or follow up.

Exclusion Criteria

Woman diagnosed with any type of cancer besides ovarian cancer.
Previous intra-abdominal malignancies in the history

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To distinguish benign ovarium lesions from early cancer lesions, based upon<br /><br>their ctDNA en platelet RNA profile.<br /><br><br /><br>To evaluate the accuracy of prediction response of ovarian carinomas on<br /><br>therapy.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Evaluate the diagnostic accuracy of ctDNA and platelet RNA profiling in<br /><br>detecting early-stage ovarium cancer compared to healthy controls;<br /><br>Evaluate the diagnostic accuracy of ctDNA and platelet RNA profiling in<br /><br>detecting early-stage ovarium cancer compared to stage IV ovarium cancer;<br /><br>Evaluate the accuracy of ctDNA and platelet RNA profiling in differentiating<br /><br>between ovarium cancer and other tumor types.</p><br>