Coagulation Monitoring in Patients on Extracorporeal Membrane Oxygenation Hämostaseologisches Monitoring Bei Patienten Mit Extrakorporaler Membranoxygenierung
试验速览
- 阶段
- 不适用
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- platelet function parameter
研究概览
简要总结
Coagulation disorders are on top of the list of extracorporeal-membrane oxygenation (ECMO) complications. They contribute significantly to morbidity and mortality of ECMO patients. This observational study aims to evaluate coagulation profiles of ECMO patients treated on the intensive care units of the Department of Anaesthesiology of LMU Munich.
详细描述
Coagulation disorders are on top of the list of extracorporeal-membrane oxygenation (ECMO) complications. They contribute significantly to morbidity and mortality of ECMO patients. This observational study aims to evaluate coagulation profiles of ECMO patients treated on the intensive care units of the Department of Anaesthesiology of LMU Munich. Adult ECMO patients are included in the study after informed consent.
Bleeding and thromboembolic complications as well as treatment details are recorded. Additional coagulation laboratory markers (such as von-Willebrand-factor, ADAMTS13-protease, platelet function tests and thromboelastometric tests) are correlated with clinical signs of bleeding. Regular ultrasound examination of the large vessels are performed to Screen for thrombosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient treated on ICU of Department of Anesthesiology of LMU Munich
- •treated with ECMO
- •age >/= 18 years (adult patients only)
- •informed consent
排除标准
- •underage patients
- •pregnant patients
- •hemoglobin level < 8mg/dl
结局指标
主要结局
platelet function parameter
时间窗: one week after ending ECMO therapy
platelet function test
coagulation parameter
时间窗: one week after ending ECMO therapy
thromboelastometric test
次要结局
- inflammatory parameter(one week after ending ECMO therapy)
研究者
Michael Zoller MD
Principal Investigator
Ludwig-Maximilians - University of Munich
