跳至主要内容
临床试验/NCT03642912
NCT03642912Unknown不适用

Coagulation Monitoring in Patients on Extracorporeal Membrane Oxygenation Hämostaseologisches Monitoring Bei Patienten Mit Extrakorporaler Membranoxygenierung

Ludwig-Maximilians - University of Munich1 个研究点 分布在 1 个国家目标入组 35 人开始时间: 2019年1月16日最近更新:
适应症

试验速览

阶段
不适用
入组人数
35
试验地点
1
主要终点
platelet function parameter

研究概览

简要总结

Coagulation disorders are on top of the list of extracorporeal-membrane oxygenation (ECMO) complications. They contribute significantly to morbidity and mortality of ECMO patients. This observational study aims to evaluate coagulation profiles of ECMO patients treated on the intensive care units of the Department of Anaesthesiology of LMU Munich.

详细描述

Coagulation disorders are on top of the list of extracorporeal-membrane oxygenation (ECMO) complications. They contribute significantly to morbidity and mortality of ECMO patients. This observational study aims to evaluate coagulation profiles of ECMO patients treated on the intensive care units of the Department of Anaesthesiology of LMU Munich. Adult ECMO patients are included in the study after informed consent.

Bleeding and thromboembolic complications as well as treatment details are recorded. Additional coagulation laboratory markers (such as von-Willebrand-factor, ADAMTS13-protease, platelet function tests and thromboelastometric tests) are correlated with clinical signs of bleeding. Regular ultrasound examination of the large vessels are performed to Screen for thrombosis.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • patient treated on ICU of Department of Anesthesiology of LMU Munich
  • treated with ECMO
  • age >/= 18 years (adult patients only)
  • informed consent

排除标准

  • underage patients
  • pregnant patients
  • hemoglobin level < 8mg/dl

结局指标

主要结局

platelet function parameter

时间窗: one week after ending ECMO therapy

platelet function test

coagulation parameter

时间窗: one week after ending ECMO therapy

thromboelastometric test

次要结局

  • inflammatory parameter(one week after ending ECMO therapy)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Michael Zoller MD

Principal Investigator

Ludwig-Maximilians - University of Munich

研究点 (1)

Loading locations...

相似试验