JPRN-UMIN000012515
Not yet recruiting
Phase 2
To evaluate the efficacy and safety of Erlotinib and Bevacizumab in patients with advanced Non-squamous Non-Small Cell Lung Cancer with brain metastasis who acquired resistance to prior EGFR-TKI treatment harboring EGFR mutation. - To evaluate the efficacy and safety of Erlotinib and Bevacizumab in patients with advanced Non-squamous Non-Small Cell Lung Cancer with brain metastasis who acquired resistance to prior EGFR-TKI treatment harboring EGFR mutation.
Department of Respiratory Medicine, Kumamoto University Hospital0 sites16 target enrollmentStarted: December 9, 2013Last updated:
Conditionson-Small-Cell Lung Cancer
Overview
- Phase
- Phase 2
- Status
- Not yet recruiting
- Sponsor
- Department of Respiratory Medicine, Kumamoto University Hospital
- Enrollment
- 16
Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 20years-old to ot applicable (—)
- Sex
- All
Inclusion Criteria
- Not provided
Exclusion Criteria
- •first enrollment 1\)Squamous cell carcinoma 2\)brain metastasis 3\)Pregnant or breast\-feeding females second enrollment 1\)Interstitial pneumonia or pulmonary fibrosis on chest CT scans 2\)History of EGFR\-TKI, VEGF antibody allergic reaction. 3\)Radiotherapy enforcement example for the brain 4\)Brain metastasis expected bleeding 5\)Active severe comorbidity disease. 6\)History of hemoptysis 7\)Uncontrollable hypertension 8\)History of gastrointenstinal perforation or diverticulitis or fistula 9\)Scheduled operation 10\)Active concomitant malignancy 11\)Pregnant or breast\-feeding females 12\)Inappropriate patients for this study judged by the physicians
Investigators
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