Rhythmic Walking Program and Renal Function and Oxidative Stress

Not Applicable

Completed

• Conditions: Renal Function

• Registration Number: NCT07059559
• Lead Sponsor: Burapha University

Brief Summary

This study designed a over-knee automatic step counter device. Then, we evaluated its efficacy on renal function and oxidative stress in patients with chronic kidney disease.

Detailed Description

This study is a randomized controlled trial. Patients who consent to participate and pass the screening process will be randomly assigned to groups based on the order of their participation (random by sequence). Patients who join in odd-numbered order, such as 1st, 3rd, 5th, etc., will receive standard care as provided by the hospital (control group). Patients who join in even-numbered order, such as 2nd, 4th, 6th, etc., will receive a walking program. This involves continuous walking exercise for 30 minutes, once a day, three days a week, over a period of three months. During the walking sessions, patients will walk at a pace of 60 steps per minute, or one step per second.

Study Timeline

• Study Start: 2024-07-17
• Status Verified: 2025-07
• Primary Completion: 2025-07-01
• Study Completion: 2025-07-01
• Study First Submitted: 2025-07-01
• Study First Submitted QC: 2025-07-01
• Last Update Submitted: 2025-07-01
• Study First Posted: 2025-07-11
• Last Update Posted: 2025-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Male or female
• Aged between 18 and 59 years
• Diagnosed by a physician with chronic kidney disease stage 2-4, with a glomerular filtration rate (GFR) between 15-89 milliliters per minute, persisting for at least 3 months

Exclusion Criteria

• No musculoskeletal disorders that hinder walking, such as osteoarthritis
• Not engaging in regular exercise (less than 3 times per week or less than 150 minutes per week)
• Not regularly taking medications or supplements containing antioxidants

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Creatinine level	Day 0 and day 91	Blood creatinine level was measured in mg/dL unit
Malondialdehyde level	Day 0 and day 91	Blood malondialdehyde level was measured in micromolar unit
Superoxide dismutase activity level	Day 0 and day 91	Blood superoxide dismutase activity level was measured in percent unit
Estimated glomerular filtration rate level	Day 0 and day 91	Estimated glomerular filtration rate level was measured in ml/min/1.73 m2 unit
Estimated creatinine clearance level	Day 0 and day 91	Estimated creatinine clearance level was measured in ml/min unit

Trial Locations

Locations (1)

Rehabilitation Medicine Department, Chamni Hospital; 🇹🇭 Chamni, Buriram, Thailand