The Influence of 16:8 Time-Restricted Eating on Resistance Exercise-Induced Skeletal Muscle Hypertrophy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Changes in Muscle Size - Lower Body
研究概览
简要总结
The purpose is to examine the effects of time-restricted eating (TRE; consuming all calories within an 8-hour period each day) vs. normal eating (CON; consuming same kcals and protein as TRE, but during a 10-13 hr eating window each day) during 8 weeks of resistance exercise on body composition and muscle mass (whole muscle and single fiber), muscular performance, anabolic protein signaling, single muscle fiber characteristics, and the gut microbiome in well-trained young men and women.
详细描述
The primary goal pertains to muscle hypertrophy (not fat loss), thus all participants will be placed in a 10% caloric surplus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
Participants will know their group. Training and Nutrition research team members will know the participants group. Data analysis team will be blinded to condition.
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-35 years old with <25% (men) or <30% (women) body fat
- •have experience in resistance exercise for the whole body and performed resistance exercise at least 3 times per week the last 12 months
- •be able to perform all necessary exercises with safe technique and no pain
- •be able to squat 1.5x (men) or 1x (women) body weight
- •be able to bench press 1.1x (men) or 0.55x (women) body weight
- •be on a non-specialized, mixed macronutrient diet
- •have a lifestyle which enables a reasonably consistent 7+ hours of sleep per night
- •be free of any current joint, musculoskeletal, and/or neuromuscular injuries
排除标准
- •have any known current illness, prohibitive muscular or neuromuscular problem, hypertension, cardiac, pulmonary, liver, kidney, insulin or any other metabolic disorders (e.g. Type I or Type II diabetes)
- •are lactose intolerant or unable to consume whey protein for any reason
- •are on any medications known to affect protein metabolism
- •have taken antibiotics in the last 6 months
- •cannot refrain from consuming any alcoholic beverages, nicotine, or marijuana (or derivative) for a period of 48 hours prior to data collection (pre and post testing)
- •consume alcohol >2x per week
- •consume any analgesic or anti-inflammatory drug(s), prescription or non-prescription, chronically or within 48 hours of data collection
- •consume any recreational drug(s), prescription or non-prescription, legal or illegal, chronically or within 30 days of data collection
- •consume any caffeine or food within 12 hours of data collection
- •cannot refrain from physical exercise (outside of activities of daily living) outside of what is prescribed by the research team for the duration of the study
- •cannot refrain from using recovery methods such as electric stimulation, hot/cold therapy, massage, chiropractic, or personal air/water devices (Normatech, etc.)
- •have utilized any anabolic steroid, currently or in the past
- •cannot refrain from consumption of any supplementation (creatine, multivitamin, fish oil, protein powder, BCAA, pre-workouts, etc.) outside of what is provided
- •cannot refrain from consuming any supplemental pro or prebiotics or other items that intentionally alter the gut microbiome
- •fail to adhere to the nutritional guidelines or miss >3 of the exercise sessions
- •were recently pregnant, trying to become pregnant, or are currently breastfeeding
结局指标
主要结局
Changes in Muscle Size - Lower Body
时间窗: Pre, Mid (4 weeks), and Post (8 weeks)
via Ultrasound
Changes in Muscle Size - Upper Body
时间窗: Pre, Mid (4 weeks), and Post (8 weeks)
via Ultrasound
Changes in Fiber Type-Specific Size
时间窗: Pre and Post (week 8)
Single muscle fiber analysis
Changes in Body composition
时间窗: Pre, Mid (4 weeks), and Post (8 weeks)
via BodPod
Acute Exercise Induced Fiber Type-Specific Anabolic Signaling (Total Concentration and Phosphorylation Status)
时间窗: Day 1 of exercise training
Men only; assessed via single fiber Simple Western
次要结局
- Changes in Maximal Strength(Pre and Post (week 8))
- Changes in Maximal Muscular Endurance(Pre and Post (week 8))
- Changes in Enjoyment of Diet(Weekly for duration of the intervention (8 weeks))
- Changes in Sleep (total and quality)(Weekly for duration of the intervention (8 weeks))
- Changes in Gut Microbiome(Pre, Mid (week 2, 4, 6), and Post (week 8))
- Changes in Fiber Type Composition(Pre and Post (week 8))
- Changes in Fiber Type-Specific Resting Anabolic Signaling (Total Concentration and Phosphorylation Status)(Pre and Post (week 8))
- Changes in Menstrual Cycle(Pre, Mid (week 4), and post (week 8))
- Total Training Volume(After 8 weeks)
- Nutrient Intake(Daily, starting 7 days before the study and continuing for 8 additional weeks)
- Changes in Mood(Weekly for duration of the intervention (8 weeks))
研究者
Andrew Galpin
Associate Professor
California State University, Fullerton