Evaluation and testing of the microvascular function in asymptomatic athletes
- Conditions
- Microvasculair functionthe function of the smaller cardiac blood vessels10028593
- Registration Number
- NL-OMON44625
- Lead Sponsor
- Cardiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 22
Index group: asymptomatic athletes with concordant abnormal exercise electrocardiography results and abnormal myocardial perfusion scintigraphy results but without the presence of epicardial coronary artery disease. ;An athlete is defined as a sportsmen who is engaged in sports for at least 2.5 hours a week for a period of minimally 30 weeks per year or in two or more sports with a minimum of 1.5 hours per week within one type of sports for at least 20 weeks per year;Control group: Individuals with a low a priori risk of CAD and without presence of significant epicardial coronary artery disease who last year already have undergone PET/CT as part of a prior diagnostic procedure.
Symptomatic athletes ((Exercise induced) chest pain, palpitations, dizziness, light headiness or syncope), athletes with epicardial coronary artery disease, athletes with previous myocardial infarction
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* Myocardial blood flow (MBF) per gram of myocardial tissue (ml/min/g) with<br /><br>82Rb PET-CT imaging.<br /><br>* Myocardial flow reserve (MBF at peak hyperaemia / MBF at rest) with 82Rb<br /><br>PET-CT imaging.</p><br>
- Secondary Outcome Measures
Name Time Method <p>* The plasma levels of eNOS and ET-1 in athletes with a normal and abnormal<br /><br>exercise test result.</p><br>