Trial of a Brain Preservation Diet in Preventing Cognitive Decline in Old Age Hostel Residents

Not Applicable

Completed

• Conditions: Cognitive Decline; Dietetic Intake
• Interventions: Other: "brain preservation' diet

• Registration Number: NCT01132261
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

Dementia is a major cause of disabilities in older people. If the onset of dementia can be delayed by preventive measures, the burden of the disease to the society can be greatly reduced. It is now recognised that dietary factors are related to the incidence of dementia. High intake of vegetables, fruit and fish are protective while high intake of saturated fat and salt (via its effect on blood pressure) are detrimental to risk of dementia.

The investigators therefore propose to perform a randomized controlled trial of dietetic interventions in old age hostels in Hong Kong. Twelve old age hostels under the Tung Wah Group will be randomly assigned to intervention or control groups. The intervention group will receive dietetic interventions by 2 weekly small group discussion with the residents, modification of menu and publicity. The daily diet to be implemented consists of the following principles: 1. fresh fruit 2 portions, 2. vegetables 4 portions, 3. fish, 4. white meat, 5. sodium intake \< 100 mmol/L, 6. six glasses of water. In the control group. The dietician will give two health talks and advice on menu only.

The primary outcome is the incidence of questionable dementia in those who are normal at baseline and the incidence of dementia in those who have questionable dementia at baseline. The categorisation will be performed by trained research assistant after administering a structured questionnaire. Change in mini-mental examination score and SF36 quality of life scores are secondary outcomes. Food records over three days for each subject are recorded every three months, to ensure that the brain preservation diet has been adhered to. Half of the subjects will be randomly assigned to have blood and urine tests at baseline and at one year, in order to examine the health effects of dieting.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-02
• Status Verified: 2009-01
• Primary Completion: 2009-06
• Study Completion: 2009-06
• Study First Submitted: 2010-05-25
• Study First Submitted QC: 2010-05-27
• Last Update Submitted: 2010-05-27
• Study First Posted: 2010-05-28
• Last Update Posted: 2010-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 480

Inclusion Criteria

• old age home residents age 75 years or above, CDR<1

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Exclusion Criteria

• tube fed residents

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	"brain preservation' diet	brain preservation diet

Primary Outcome Measures

Name	Time	Method
cognitive decline	33 months

Secondary Outcome Measures

Name	Time	Method
Change in MMSE test	33 months
% subjects meeting targets of brain preservation diet	33 months	brain preservation diet includes 3 portion of vergetables per day, 2 portion of fruit per day, 5 meal of fish per week, 6 glasses of water per day.

Trial Locations

Locations (1)

The Chinese University of Hong Kong; 🇨🇳 Hong Kong, China