Assessment of pathological complete response rates with the addition of carboplatin to the sequential taxane-anthracycline chemotherapy in patients with non metastatic triple negative breast cancer

Neoadjuvant chemotherapy is the preferable approach in patients with locally advanced TNBC.Achieving pCR is considered an essential prognostic factor with long term outcomes. It has been seen that in previous studies , addition of carboplatin to the sequential Taxane-anthracycline regimen has been found to improve pCR compared to the routinely used Anthracycline-taxane regimen. But most of these studies have compared weekly administration regimen of platins and taxanes.  In our study we will compare the pathological complete response rates between two arms – In one arm , we will take the historical controls of patients who had received Anthracycline – Taxane chemotherapy from our existing medical records  In the other arm , we will add Carboplatin at AUC 5 given 3 weekly to the sequential Taxane – Anthracycline chemotherapy.. Making the regimen 3 weekly , we will be able to ensure good compliance and adherence of the patient to chemotherapy and also reduce their expenses as most of our patients travel from relatively far places for chemotherapy and importantly seeing to it that there IS NO compromise on response.