NL-OMON38881
Completed
Not Applicable
A 4-period study to investigate the effects of d-amphetamine on psychomotor function in relation to dopamine release capacity in healthy male subjects - Amphetamine PET study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- method development for further drug research
- Sponsor
- Centre for Human Drug Research
- Enrollment
- 16
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age between 25 and 45 (inclusive);Body Mass Index (BMI) between 18 and 30 kg/m2 (inclusive);Naïve to drugs containing amphetamine, cocaine or MDMA (ecstacy). This includes medically prescribed amphetamines or methylphenidate. Past (but not current) recreational use of THC, or use of nicotine is allowed.;Signed informed consent prior to any study\-mandated procedure.;Ability to communicate well with the investigator in the Dutch language
Exclusion Criteria
- •Clinically significant (history of) disease as determined by medical history, physical examination, ECG or routine blood chemistry, hematology or virology tests;Clinically significant (history of) psychiatric illnesses (including substance abuse) or (history of) psychotic symptoms;Family history of relevant psychiatric disorders (first degree) and/or psychotic disorders (first and second degree);Smokes more than 10 cigarettes a day and unwilling/unable to refrain from smoking during study occasions;Positive urine drug screen for recreational drugs (i.e. cocaine, opioids, benzodiazepines, amphetamines, metamphetamines, MDMA and/or THC);Blood loss or donation outside the limits of the Dutch blood bank (Sanquin) ;Participation in a clinical study within the past three months, or participation in four or more clinical studies in the past twelve months;Exposure to procedures involving radiation in the year prior to study start.
Outcomes
Primary Outcomes
Not specified
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