NL-OMON38881
已完成
不适用
A 4-period study to investigate the effects of d-amphetamine on psychomotor function in relation to dopamine release capacity in healthy male subjects - Amphetamine PET study
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- method development for further drug research
- 发起方
- Centre for Human Drug Research
- 入组人数
- 16
- 状态
- 已完成
- 最后更新
- 2年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •Age between 25 and 45 (inclusive);Body Mass Index (BMI) between 18 and 30 kg/m2 (inclusive);Naïve to drugs containing amphetamine, cocaine or MDMA (ecstacy). This includes medically prescribed amphetamines or methylphenidate. Past (but not current) recreational use of THC, or use of nicotine is allowed.;Signed informed consent prior to any study\-mandated procedure.;Ability to communicate well with the investigator in the Dutch language
排除标准
- •Clinically significant (history of) disease as determined by medical history, physical examination, ECG or routine blood chemistry, hematology or virology tests;Clinically significant (history of) psychiatric illnesses (including substance abuse) or (history of) psychotic symptoms;Family history of relevant psychiatric disorders (first degree) and/or psychotic disorders (first and second degree);Smokes more than 10 cigarettes a day and unwilling/unable to refrain from smoking during study occasions;Positive urine drug screen for recreational drugs (i.e. cocaine, opioids, benzodiazepines, amphetamines, metamphetamines, MDMA and/or THC);Blood loss or donation outside the limits of the Dutch blood bank (Sanquin) ;Participation in a clinical study within the past three months, or participation in four or more clinical studies in the past twelve months;Exposure to procedures involving radiation in the year prior to study start.
结局指标
主要结局
未指定
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