The Cognitive Effects of Lorazepam in Healthy Older Individuals With TOMM40 Variable-length Polymorphisms
Overview
- Phase
- Phase 1
- Intervention
- lorazepam
- Conditions
- Alzheimer's Disease (AD)
- Sponsor
- Mayo Clinic
- Enrollment
- 57
- Locations
- 1
- Primary Endpoint
- Groton Maze Learning Test (GMLT) score
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The investigators' goal is to determine if certain tests of memory and attention, performed while sleepiness is induced by a single dose of lorazepam, can predict whether or not an individual is at risk for developing Alzheimer's disease.
Investigators
Cynthia M. Stonnington, M.D.
PI
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
L/VL APOE e3/e4 carrier
long and very long poly - T variants of TOMM40 and APOE e3/e4 carrier
Intervention: lorazepam
L/S APOE e3/e4 carrier
long and short poly - T variants of TOMM40 and APOE e3/e4 carrier
Intervention: lorazepam
S/VL APOE e3/e3 carrier
short and Very long poly - T variants of TOMM40 and APOE e3/e3 carrier
Intervention: lorazepam
VL/VL APOE e3/e3 carrier
Very long poly - T variants of TOMM40 and APOE e3/e3 carrier
Intervention: lorazepam
S/S APOE e3/e3 carrier
short poly - T variants of TOMM40 and APOE e3/e3 carrier
Intervention: lorazepam
Outcomes
Primary Outcomes
Groton Maze Learning Test (GMLT) score
Time Frame: baseline to 5 hours
The GMLT assesses visuospatial working memory, error monitoring, information processing speed, and short-term delayed recall for a complex hidden maze. Subjects are familiarized with the task during two untimed practice tests, and once the tester is confident that the subject understands the rules and can move easily around the grid, the timed test is administered. In each of the 5 successive trials of the GMLT exam, the subject is asked to learn to navigate his or her way around a 28-step maze that is hidden beneath a 10 x 10 grid of squares on the computer touch screen. For each trial, the time to completion, number of correct moves, number of wrong moves, and the number of perseverative errors are recorded.
Secondary Outcomes
- Auditory Verbal Learning Test (AVLT) Long-term memory score(baseline to 5 hours)
- Two Back Test (TBK)(baseline to 5 hours)