Elevated LDH Serum Levels and FDG-PET in Metastatic Melanoma Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- Independent correlation between baseline serum LDH level and 18F-FDG uptake of tumour lesions
研究概览
简要总结
A retrospective study investigating the relationship between FDG-PET uptake and LDH levels.
详细描述
Patient characteristics, tumour characteristics including the BRAF mutation status and baseline serum S100B and LDH levels of each patient will be retrospectively determined from the electronical patient file. In each patient, tumour burden and 18F-FDG uptake of the tumour lesions will be measured using multiple standard quantification parameters of the baseline 18F-FDG-PET scan. Tumour burden will also be measured on the baseline contrast enhanced CT scan. The correlation of each FDG-PET parameter with baseline LDH and S100B levels, respectively, will be analyzed using univariate and multivariate regression analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients >18 years with histologically proven metastatic melanoma (American Joint Committee on Cancer [AJCC] stage IV melanoma) treated in the UMCG between May 2014 and December 2015.
排除标准
- •participation in interventional studies
- •missing baseline 18F-FDG PET scan and/or baseline contrast enhanced CT scan
- •missing baseline serum LDH level
- •missing BRAF mutation status, concurrent malignancies or a history of previous malignancies.
结局指标
主要结局
Independent correlation between baseline serum LDH level and 18F-FDG uptake of tumour lesions
时间窗: 3 months
次要结局
- Correlation between baseline serum S100B level and tumour 18F-FDG uptake(3 months)
- Correlation of baseline serum LDH level with tumour volume as measured on CT scan and as measured on 18F-FDG-PET scan(3 months)
- Difference between tumour volume as determined by manual measurement or semiautomatic measurement(3 months)
- Correlation between baseline serum LDH level and tumour 18F-FDG uptake in subgroups separated by metastasis site(3 months)
- Difference between tumour burden as measured on CT scan and on 18F-FDG-PET(3 months)