To find the number of cancer patients having lower than normal healthy red blood cell due to low iron in body, and how this affects their treatment

Not Applicable

Conditions: Health Condition 1: C00-D49- Neoplasms

Registration Number: CTRI/2022/06/043104

Lead Sponsor: Dr Malini Mohan

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Hemoglobin level less than or equal to 10 g/dL

- Transferrin saturation < 20 %

- Any stage solid malignancies

Exclusion Criteria

- Age less than 18yrs

- Pregnant women

- any evidence of hemolysis

- Active gastrointestinal bleeding (stool occult blood positive)

- active infection requiring systemic antibiotics

- HIV infection

- active Tuberculosis infection

- liver/ renal dysfunction - Grade 2 or higher based on National Cancer Institute Common Toxicity Criteria: Bilirubin >1.5 times normal, Transaminases >2.5 times normal), renal dysfunction (serum creatinine levels > or equal to 2.0 mg/dL)

- Malignant Bone marrow infiltration

-Received iron supplementation / blood transfusion in the preceding 4 weeks

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of patients with absolute and functional iron deficiency anemia <br/ ><br>Timepoint: 2 years

Secondary Outcome Measures

Name	Time	Method
a)Best response to treatment - Response will be defined as proportion of patients achieving an increase in hemoglobin at any time from baseline to end of 12 weeks. Response criteria is defined as follows: - <br/ ><br>Complete response : increase in Hemoglobin level 2.0 g/dL above baseline, and/ or transfusion free. <br/ ><br>Partial response : increase in Hemoglobin level (1g/dL-2g/dL) above baseline <br/ ><br>Minor response : increase in Hemoglobin level ( 0.5 g/dL-1g/dL) above baseline <br/ ><br> <br/ ><br>b)Efficacy assessment with quality of life questionnaire (Functional assessment of cancer therapy- Anemia ( FACT An )) <br/ ><br>Timepoint: 2 years