Efficacy of Propafenone Versus Dronedarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation
- Registration Number
- NCT01991119
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
the purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion
- Detailed Description
Atrial fibrillation is the most common arrhythmia requiring continuous therapy. Conversion to and maintenance of sinus rhythm is important. Propafenone and dronedarone has been used as treatment for maintenance of sinus rhythm after DC cardioversion. But there are no direct comparison study.
The purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 98
Inclusion Criteria
- a patient with persistent atrial fibrillation who received successful DC cardioversion
Exclusion Criteria
- prior amiodarone use
- NYHA class III or IV heart failure
- Left ventricular ejection fraction < 35%
- second or third AV block
- sick sinus syndrome
- heart rate < 50 beat per minute
- myocardiac infarction within 3 months
- pregnant women
- severe hepatic dysfunction
- QT prolongation > 500ms or PR interval > 180ms
- history of hypersensitivity for drug
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Propafenone Propafenone Propafenone group Dronedarone Dronedarone Dronedarone group
- Primary Outcome Measures
Name Time Method recurrence of atrial fibrillation 6 month
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Cardiac and Vascular Center
🇰🇷Seoul, Korea, Republic of