NCT01991119已完成不适用
Efficacy of Propafenone Versus Dronedarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation After DC Cardioversion
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- recurrence of atrial fibrillation
研究概览
简要总结
the purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion
详细描述
Atrial fibrillation is the most common arrhythmia requiring continuous therapy. Conversion to and maintenance of sinus rhythm is important. Propafenone and dronedarone has been used as treatment for maintenance of sinus rhythm after DC cardioversion. But there are no direct comparison study.
The purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •a patient with persistent atrial fibrillation who received successful DC cardioversion
排除标准
- •prior amiodarone use
- •NYHA class III or IV heart failure
- •Left ventricular ejection fraction < 35%
- •second or third AV block
- •sick sinus syndrome
- •heart rate < 50 beat per minute
- •myocardiac infarction within 3 months
- •pregnant women
- •severe hepatic dysfunction
- •QT prolongation > 500ms or PR interval > 180ms
- •history of hypersensitivity for drug
研究组 & 干预措施
Propafenone
Active Comparator
Propafenone group
干预措施: Propafenone (Drug)
Dronedarone
Active Comparator
Dronedarone group
干预措施: Dronedarone (Drug)
结局指标
主要结局
recurrence of atrial fibrillation
时间窗: 6 month
次要结局
未报告次要终点
研究者
Young Keun On
Principle investigator
Samsung Medical Center
研究点 (1)
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