NCT05410665Unknown不适用
The Roles of IL-9/E-cadherin and Ferroptosis in Intestinal Mucosal Barrier Injury in Sepsis
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Incidence of intestinal barrier injury incidence of intestinal barrier injury
研究概览
简要总结
The investigators aim to evaluate the roles of IL-9/E-cadheirin and ferroptosis in the intestinal mucosal barrier injury of sepsis. The results of this study would lay the foundation for revealing the mechanisms of EEN improving immune imbalance of sepsis and provide a new idea to the early treatment of sepsis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of sepsis
- •Within 3 days of sepsis onset before ICU admission
- •No artificial nutrition (enteral or parenteral nutrition) were provided before ICU admission
排除标准
- •Digestive tract hemorrhage
- •Inflammatory bowel disease
- •Cancer or chronic organ dysfunction (e.g., hepatic or renal dysfunction)
- •Malnutrition or immunodeficiency
- •Long-term use of hormones
结局指标
主要结局
Incidence of intestinal barrier injury incidence of intestinal barrier injury
时间窗: 7 days
intestinal barrier injury
次要结局
- Incidence of ferroptosis(7 days)
研究者
研究点 (1)
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