Effects of Joint Effusion on Quadriceps Muscle

Not Applicable

Completed

• Conditions: Knee Osteoarthritis
• Interventions: Other: sham injection; Other: normal saline injection

• Registration Number: NCT01314820
• Lead Sponsor: The Catholic University of Korea

Brief Summary

The present study investigated whether the presence of fluid in the joint affected peak torque and the root mean square (RMS) values of surface electromyography (EMG) in patients symptomatic for osteoarthritis (OA).

Detailed Description

Several studies have shown that knee effusion influenced quadriceps muscle activity and induced quadriceps arthrogenic muscle inhibition in normal volunteers. However, the effect of joint effusion on the quadriceps of patients with OA is controversial,and few patients with OA have been included in studies of joint effusion.

Study Timeline

• Study Start: 2009-06
• Status Verified: 2010-01
• Primary Completion: 2010-01
• Study Completion: 2010-06
• Study First Submitted: 2011-03-14
• Study First Submitted QC: 2011-03-14
• Last Update Submitted: 2011-03-14
• Study First Posted: 2011-03-15
• Last Update Posted: 2011-03-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

• 50 years old or older with knee osteoarthritis
• knee pain without joint effusion confirmed by ultrasonography

Exclusion Criteria

• the presence of knee joint effusion determined using US
• a history of knee injury or surgery
• a history of knee injection within 3 months
• a history of inflammatory arthritis
• taking anticoagulants
• balance or gait disturbance
• diabetes mellitus

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
sham injection	sham injection	knee injection without saline
normal saline injection	normal saline injection	20 cc normal saline injection into the knee joint

Primary Outcome Measures

Name	Time	Method
the peak torque of the knee extensors	within 5 minutes after intervention	to evaluate the effect of effusion on the peak torque of the knee extensors

Secondary Outcome Measures

Name	Time	Method
the root mean square values of the vastus medialis and vastus lateralis muscles	within 5 minutes after intervention	to evaluate the effect of effusion on the RMS of the vastus medialis (VM) and vastus lateralis (VL) muscles

Trial Locations

Locations (1)

Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea; 🇰🇷 Seoul, Korea, Republic of