Influence of Enteral Microbiome Composition and Microbiome Dependent Metabolites on Mortality of Patients With Cardiogenic Shock
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiogenic Shock
- Sponsor
- University Hospital, Essen
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Correlation between enteral microbiome composition and mortality
- Status
- Completed
- Last Updated
- 8 months ago
Overview
Brief Summary
Cardiogenic shock is associated with a high mortality. The microbiome is a double-edged sword which can convey protective and detrimental cardiovascular effects. The significance of the enteral micobiome on cardiovascular mortality of patients with cardiogenic shock is still not known.
This study aims to provide a deeper understanding of the role of the enteral microbiome and microbiome dependent metabolites in mortality and disease progression of patients with cardiogenic shock.
Investigators
Chistos Rammos
Professor Dr. med.
University Hospital, Essen
Eligibility Criteria
Inclusion Criteria
- •signs of cardiogenic shock regardless of etiology
- •lactate \>3mmol/L
- •and signs of organ dysfunction (urine output \<30 ml/h, cold extremities, altered mental status)
- •and systolic blood pressure \<90 mmHg for \>30 minutes or need for vasopressor therapy
Exclusion Criteria
- •pregnancy/lactation period
- •antibiotic treatment within \>24h
- •chronic inflammatory bowel disease
- •short bowel syndrome
- •artificial bowel outlet
- •persistent diarrhea or vomiting in the past 3 months
- •simultaneous participation in another interfering nutrition study
- •active chemo or radiation therapy
Outcomes
Primary Outcomes
Correlation between enteral microbiome composition and mortality
Time Frame: Sampling will be performed within 24 hours of onset of cardiogenic shock and clinical evaluation will be performed after 1 month
Stool samples are collected and clinical evaluation will be performed at below mentioned time points
Secondary Outcomes
- Correlation between SCFA serum level and mortality(Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3)
- Correlation between TMAO serum level and mortality(Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3)
- Correlation between inflammatory profile (CRP, PCT, Interleukin panel) and mortality(Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3)