Influenza and the Heart: An Investigation Into the Acute and Lasting Cardiac Effects of Influenza Infection
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 241
- 试验地点
- 4
- 主要终点
- Rate of cardiac dysfunction
研究概览
简要总结
"Influenza and the Heart: An investigation into the acute and lasting cardiac effects of influenza infection" the investigators aim to assess the mechanisms for cardiovascular disease in patients suffering an acute influenza infection. The project will be carried out by creating a prospective clinical cohort study of consecutive patients hospitalized at Herlev & Gentofte University Hospital with a laboratory confirmed influenza.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients hospitalized at Herlev & Gentofte University Hospital with a laboratory-confirmed diagnosis of influenza
- •> 18 years of age
排除标准
- •Persons not able to cooperate
- •Persons unable to understand and sign "informed consent"
- •Pregnancy
- •Persons simultaneously positive with COVID-19
结局指标
主要结局
Rate of cardiac dysfunction
时间窗: 3 years
Defined by impaired echocardiographic parameters and elevated cardiac biomarkers - NT \- pro \- BNP annd hs \- TNT
Number of patients developing cardiovascular complications
时间窗: 3 years
Including new-onset heart failure, worsening of current heart failure, acute myocardial infarction, and cardiac arrest
Number of patients developing in-hospital mortality
时间窗: 3 years
Prevalence of elevated biomarkers of infection/inflammation
时间窗: 3 years
Prevalence of elevated biomarkers of infection/inflammation and it association with cardiac dysfunction
Rate of pulmonary embolisms diagnosed with CT thorax angiography
时间窗: 3 years
次要结局
未报告次要终点
研究者
Tor Biering-Sørensen
Associate Professor and Research Director
University Hospital, Gentofte, Copenhagen