A Comparative study of infusion of Ephedrine and Phenylephrine on hemodynamic stability after Spinal Anaesthesia in elderly patients undergoing lower limb Orthopaedic Surgeries
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Enrollment
- 174
- Locations
- 1
- Primary Endpoint
- To compare the effect of Ephedrine and Phenylephrine on hemodynamic stability after spinal anaesthesia
Study Overview
Brief Summary
This study is a Prospective Randomized, Parallel group study. This study consists of 3 groups where Group E who will receive Injection EPHEDRINE 30mg infusion for 30 minutes, Group P who will receive Injection PHENYLEPHRINE 250mcg infusion for 30 minutes and Control group will receive intravenous bolus injection mephentermine 6mg when required .174 patients posted for lower limb orthopedic surgeries under Spinal Anesthesia will be equally divided into 3 groups as 58 each. The study will be conducted in Shri. BM Patil Medical College Hospital and Research Centre Vijayapura, Karnataka. The primary outcome is to compare the effect of Ephedrine and Phenylephrine on hemodynamic stability after Spinal Anesthesia and secondary outcome is to compare the number of rescue doses of Ephedrine and Phenylephrine given after Spinal Anesthesia.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Not Applicable
Eligibility Criteria
- Ages
- 60.00 Year(s) to 90.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Age above 60 years Patients undergoing lower limb orthopaedic surgeries.
Exclusion Criteria
- •Infection at the site of injection Uncontrolled hypovolemia Allergy or Hypersensitivity to Vasoconstrictors Increased intracranial pressure Coagulopathy,sepsis,fixed cardiac output states,neurological disease Uncontrolled Hypertension,Diabetes Mellitus and Heart failure Phaeochromocytoma Hypothyroidism MAO inhibitors,Tricyclic Antidepressants Phenothiazine compounds Recent MI and CABG.
Outcomes
Primary Outcomes
To compare the effect of Ephedrine and Phenylephrine on hemodynamic stability after spinal anaesthesia
Time Frame: 30 minutes
Secondary Outcomes
- To compare the number of rescue doses of Ephedrine and Phenylephrine given after spinal anaesthesia(30 minutes)