A Randomized Controlled Trial Comparing a Fully Closed Loop Ventilation Mode (Intellivent ASV) With Pressure Controlled + Pressure Support Ventilation in COPD Patients
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Chronic Obstructive Pulmonary Disease
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
- Enrollment
- 88
- Locations
- 1
- Primary Endpoint
- Duration of intubation
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study will evaluate the effect of a fully closed loop ventilation mode (Intellivent ASV) on the duration of ventilation compared to conventional modes in COPD patients.
Detailed Description
COPD patients often need invasive mechanical ventilation and due to the difficulties in the weaning of these patients, duration of mechanical ventilation can be relatively longer when compared with other ICU patients. Automated systems show promising results in shortening the weaning time in some patient groups. The aim of this study is to evaluate the effect of Intellivent-ASV with Quickwean function on the total duration of invasive mechanical ventilation as a primary outcome. Secondary outcomes are success rate and duration of weaning, ventilator free days at day 28 and intubation free days at day 28 (including NIV) when compared to conventional ventilation with t-piece weaning.
Investigators
Cenk Kirakli, M.D.
Associate Professor, Pulmonary and Critical Care Medicine
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •COPD patients intubated and mechanically ventilated for less than 24 hours (Including patients who received NIV before intubation)
- •Age \> 18 years
- •Written and/or informed consent
Exclusion Criteria
- •Septic shock
- •Tracheostomy and/or home mechanical ventilation
- •Expected poor short term prognosis
- •Cardiac arrest with a poor neurological prognosis
- •Broncho-pleural fistula
Outcomes
Primary Outcomes
Duration of intubation
Time Frame: 24th month
Time from intubation until extubation
Duration of mechanical ventilation (NIV included)
Time Frame: 24th month
Total time patient remains on mechanical ventilation support (invasive or noninvasive)
Secondary Outcomes
- Weaning duration(24th month)
- Time spent on spontaneous ventilation(24th month)
- Number of manual settings(24th month)
- Number of blood gas analysis tests(24th month)