Can a breath hold PET/CT improve the detection and assessment of metastatic liver lesions?
Not Applicable
- Conditions
- Cancer metastasisCancer - Any cancer
- Registration Number
- ACTRN12624000422527
- Lead Sponsor
- Tony Bose
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 26
Inclusion Criteria
Age 50 years and over.
Referred for initial staging or restaging of cancer any type with suspected or confirmed multiple liver metastases (two or more).
Able to breath hold for at least 20 seconds
Exclusion Criteria
Pregnant or breastfeeding
Recent imaging (CT or MR) within 90 days reporting a reduction in metastatic liver tumour size and/or number.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in standardized uptake value (SUV) between standard PET/CT and breath hold PET/CT.[Standardized uptake value (SUV) maximum, this is recorded by the study doctors on the case report form. Single timepoint, at diagnostic investigation (PET/CT).]
- Secondary Outcome Measures
Name Time Method Total number of metastatic liver lesions[Study doctors (radiologist and radiology trainee) will review the PET/CT imaging data and count the number of lesions. This will be recorded in the case report form. This will be performed at a single timepoint, at the time (or 1-2 days) following the diagnostic investigation, this will be recorded in the case report form. ];Difference in metabolic tumour volume between standard PET/CT and breath hold PET/CT for metastatic liver lesions[metabolic isocontoured volume. Study doctors (radiologist and radiology trainee) will review the PET/CT imaging data and determine this using the available imaging software tools. This is a calculated value, and represent the total volume of a given of consistent metabolic activity within a tumour (in this case, and is standard we use 40% of the maximum uptake value). Single timepoint, at the time of (or 1-2 days following) the diagnostic intervention (PET/CT), and will be documented in the case report form.]