Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer
- Conditions
- Prostate Cancer
- Interventions
- Radiation: Dose-Escalated Radiation TherapyDrug: LHRH agonist (antagonist) therapy
- Registration Number
- NCT00936390
- Lead Sponsor
- Radiation Therapy Oncology Group
- Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and shrink tumors. Androgens can cause the growth of prostate cancer cells. Androgen-deprivation therapy may lessen the amount of androgens made by the body. It is not yet known whether radiation therapy is more effective with or without androgen-deprivation therapy in treating patients with prostate cancer.
PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with androgen-deprivation therapy in treating patients with prostate cancer.
- Detailed Description
OBJECTIVES:
Primary
* Demonstrate an overall survival (OS) advantage in patients with intermediate-risk prostate cancer treated with dose-escalated radiotherapy (RT) with versus without short-term androgen-deprivation therapy (ADT).
Secondary
* Determine whether the addition of ADT to dose-escalated RT versus RT alone improves clinical failures, biochemical failure by the "nadir +2", freedom from failure, rate of salvage ADT, and prostate cancer-specific mortality in these patients.
* Estimate the magnitude of benefit of ADT with respect to OS in patients treated with different RT modalities (i.e., external-beam radiation therapy alone vs low-dose rate brachytherapy boost vs high-dose rate brachytherapy boost).
* Compare acute and late treatment adverse events of these regimens and correlate these events with the presence or absence of pre-existing comorbidity as documented by the Adult Comorbidity Evaluation 27 assessment.
OUTLINE: This is a multicenter, dose-escalation study of radiotherapy. Patients are stratified according to number of risk factors (1 vs 2-3), comorbidity (ACE-27 grade ≥ 2 vs \< 2), and radiotherapy (RT) modality (dose-escalated external-beam RT \[EBRT\] vs EBRT and low-dose rate brachytherapy boost vs EBRT and high-dose rate brachytherapy boost). Patients are randomized to 1 of 2 treatment arms. After completion of study therapy, patients are followed up periodically.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- Male
- Target Recruitment
- 1538
-
Pathologically (histologically) proven diagnosis of prostatic adenocarcinoma, at intermediate risk for recurrence, within 180 days prior to registration as determined by having one or more of the following intermediate-risk features: Gleason score 7; prostate-specific antigen (PSA) >10 but ≤20; clinical stage T2b-T2c.
- Patients previously diagnosed with low risk (Gleason score ≤ 6, clinical stage < T2a, and PSA < 10) prostate cancer undergoing active surveillance who are re-biopsied and found to have intermediate risk disease according to the protocol criteria are eligible for enrollment within 180 days of the repeat biopsy procedure.
-
Clinically negative lymph nodes as established by imaging (pelvic +/- abdominal CT or MRI), nodal sampling, or dissection within 60 days prior to registration, except as noted immediately below:
- Patients with a single intermediate risk factor only do not require abdominopelvic imaging, but these studies may be obtained at the discretion of the treating physician. Patients with 2 or 3 risk factors are required to undergo pelvic +/- abdominal CT or MRI.
- Patients with lymph nodes equivocal or questionable by imaging are eligible without biopsy if the nodes are ≤1.5 cm; any node larger than this on imaging will require negative biopsy for eligibility.
-
No evidence of bone metastases (M0) on bone scan within 60 days prior to registration.
- Bone scan is not required for patients enrolled with a single intermediate risk factor only, but this scan may be obtained at the discretion of the treating physician. Patients with 2 or 3 risk factors will require a negative bone scan for eligibility.
- Equivocal bone scan findings are allowed if plain film x-rays are negative for metastasis.
-
History/physical examination (to include, at a minimum, digital rectal examination of the prostate and examination of the skeletal system and abdomen, and formal comorbidity assessment via the ACE-27 instrument) within 60 days prior to registration.
-
Zubrod Performance Status 0-1
-
Age ≥ 18
-
Baseline serum PSA value performed with an FDA-approved assay (e.g., Abbott, Hybritech) within 60 days prior to registration
- Study entry PSA must not be obtained during the following time frames: (1) 10-day period following prostate biopsy; (2) following initiation of ADT; (3) within 30 days after discontinuation of finasteride; or (4) within 90 days after discontinuation of dutasteride.
-
For patients undergoing brachytherapy only: complete blood count (CBC)/differential obtained within 60 days prior to registration, with adequate bone marrow function defined as follows:
- Absolute neutrophil count (ANC) ≥ 1,800 cells/mm3
- Platelets ≥ 100,000 cells/mm3
- Hemoglobin (Hgb) ≥ 8.0 g/dl (Note: The use of transfusion or other intervention to achieve Hgb ≥ 8.0 g/dl is acceptable.)
-
Patient must be able to provide study-specific informed consent prior to study entry.
-
Patients with Gleason Score ≥ 8; PSA > 20; OR Clinical Stage ≥ T3 are ineligible for this trial.
- Should findings of extracapsular extension or seminal vesicle invasion be noted on prostate MRI, this study, if used, will not render patients ineligible for accrual to this protocol. Primary tumor staging for eligibility purposes is to be based on palpable or core biopsy evidence only with respect to extracapsular extension or seminal vesicle involvement.
-
Patients with all three intermediate risk factors who also have ≥ 50% of the number of their biopsy cores positive for cancer are ineligible for this trial.
-
Prior invasive malignancy (except non-melanomatous skin cancer) or hematological (e.g., leukemia, lymphoma, myeloma) malignancy unless disease free for a minimum of 5 years (prior diagnoses of carcinoma in situ are permitted)
-
Prior radical surgery (prostatectomy), high-intensity focused ultrasound (HIFU) or cryosurgery for prostate cancer
-
Prior hormonal therapy, such as LHRH agonists (e.g., goserelin, leuprolide), antiandrogens (e.g., flutamide, bicalutamide), estrogens (e.g., DES), or bilateral orchiectomy
-
Use of finasteride within 30 days prior to registration
-
Use of dutasteride within 90 days prior to registration
-
Prior or concurrent cytotoxic chemotherapy for prostate cancer; prior chemotherapy for a different cancer is permitted.
-
Prior RT, including brachytherapy, to the region of the study cancer that would result in overlap of RT fields
- Any patient undergoing brachytherapy must have transrectal ultrasound confirmation of prostate volume <60 cc, American Urological Association Symptom Index (AUA-SI) score ≤15 within 60 days of registration, and no history of prior transurethral resection of the prostate (TURP); prior TURP is permitted for patients who receive EBRT only)
-
Severe, active co-morbidity, defined as follows:
- Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
- Transmural myocardial infarction within the last 6 months
- Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
- Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days before registration
- Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for liver function and coagulation parameters are not required for entry into this protocol.
- Acquired Immune Deficiency Syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that HIV testing is not required for entry into this protocol. While the treatment employed in this study is not significantly immunosuppressive, it is felt that a diagnosis of AIDS associated with prostate cancer is likely to impact this study's primary endpoint of overall survival. Patients who are HIV seropositive but do not meet criteria for diagnosis of AIDS are eligible for study participation.
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Men who are sexually active with a woman of child-bearing potential and not willing/able to use medically acceptable forms of contraception (e.g., surgical, barrier, medicinal) during protocol treatment and during the first 3 months after cessation of protocol treatment; this exclusion is necessary because the treatment involved in this study may be significantly teratogenic.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Dose-Escalated Radiation Therapy Alone Dose-Escalated Radiation Therapy Radiation therapy consists of 79.2 Gy EBRT only or 45 Gy EBRT followed by low- or high-dose rate brachytherapy. EBRT is delivered in 1.8 Gy daily fractions. Dose-Escalated Radiation Therapy and Short-Term Androgen-Deprivation flutamide Radiation therapy consists of 79.2 Gy EBRT only or 45 Gy EBRT followed by low- or high-dose rate brachytherapy. EBRT is delivered in 1.8 Gy daily fractions. Six months of androgen-deprivation therapy starts 8 weeks prior to start of radiation therapy and consists of luteinizing-hormone releasing-hormone (LHRH) agonist (antagonist) therapy (leuprolide, goserelin, buserelin. triptorelin, or degarelix) and anti-androgen therapy (bicalutamide or flutamide). Dose-Escalated Radiation Therapy and Short-Term Androgen-Deprivation LHRH agonist (antagonist) therapy Radiation therapy consists of 79.2 Gy EBRT only or 45 Gy EBRT followed by low- or high-dose rate brachytherapy. EBRT is delivered in 1.8 Gy daily fractions. Six months of androgen-deprivation therapy starts 8 weeks prior to start of radiation therapy and consists of luteinizing-hormone releasing-hormone (LHRH) agonist (antagonist) therapy (leuprolide, goserelin, buserelin. triptorelin, or degarelix) and anti-androgen therapy (bicalutamide or flutamide). Dose-Escalated Radiation Therapy and Short-Term Androgen-Deprivation Dose-Escalated Radiation Therapy Radiation therapy consists of 79.2 Gy EBRT only or 45 Gy EBRT followed by low- or high-dose rate brachytherapy. EBRT is delivered in 1.8 Gy daily fractions. Six months of androgen-deprivation therapy starts 8 weeks prior to start of radiation therapy and consists of luteinizing-hormone releasing-hormone (LHRH) agonist (antagonist) therapy (leuprolide, goserelin, buserelin. triptorelin, or degarelix) and anti-androgen therapy (bicalutamide or flutamide). Dose-Escalated Radiation Therapy and Short-Term Androgen-Deprivation bicalutamide Radiation therapy consists of 79.2 Gy EBRT only or 45 Gy EBRT followed by low- or high-dose rate brachytherapy. EBRT is delivered in 1.8 Gy daily fractions. Six months of androgen-deprivation therapy starts 8 weeks prior to start of radiation therapy and consists of luteinizing-hormone releasing-hormone (LHRH) agonist (antagonist) therapy (leuprolide, goserelin, buserelin. triptorelin, or degarelix) and anti-androgen therapy (bicalutamide or flutamide).
- Primary Outcome Measures
Name Time Method Percentage of Participants Alive (Overall Survival) From randomization to last follow-up. Follow-up schedule: end of RT (2nd arm only), then every 3 months for a year, every 4 months for 4 years, then yearly. Maximum follow-up at time of analysis was 10.3 years. Five-year rates reported here. Overall survival time is defined as time from randomization to the date of death from any cause or last known follow-up (censored). Overall survival rates are estimated by the Kaplan-Meier method. The protocol specifies that the distributions of failure times be compared between the arms, which is reported in the statistical analysis results. Five-year rates are provided here. Analysis was planned to occur after 218 deaths were reported.
- Secondary Outcome Measures
Name Time Method Quality Adjusted Life Years (QALYs) Last week of RT (approximately 9 and 17 weeks from start of protocol treatment for Arm 1 and 2, respectively), then 6 months, 1 year and 5 years from end of RT. Correlation Between PROMIS Fatigue Score Change and Plasma Cytokine Change From date of randomization to 3 weeks from start of RT. Percentage of Participants With Biochemical Failure From randomization to last follow-up. Follow-up schedule: end of RT (2nd arm only), then every 3 months for a year, every 4 months for 4 years, then yearly. Maximum follow-up at time of analysis was 10.3 years. Five-year rates reported here. Biochemical failure is defined as an increase of at least 2 ng/ml above the nadir PSA. Failure time is defined as time from randomization to the date of first failure, last known follow-up (censored), or death without failure (competing risk). Failure rates are estimated using the cumulative incidence method. The protocol specifies that the distributions of failure times be compared between the arms, which is reported in the statistical analysis results. Five-year rates are provided here. Analysis was planned to occur after 218 deaths were reported.
Percentage of Participants With Local Recurrence From randomization to last follow-up. Follow-up schedule: end of RT (2nd arm only), then every 3 months for a year, every 4 months for 4 years, then yearly. Maximum follow-up at time of analysis was 10.3 years. Five-year rates reported here. Local recurrence (failure) is defined as clinical (palpable) suspicion of local recurrence \[this date is used\] confirmed by biopsy. Failure time is defined as time from randomization to the date of first failure, last known follow-up (censored), or death without failure (competing risk). Failure rates are estimated using the cumulative incidence method. The protocol specifies that the distributions of failure times be compared between the arms, which is reported in the statistical analysis results. Five-year rates are provided here. Analysis was planned to occur after 218 deaths were reported.
Percentage of Participants With Regional Recurrence From randomization to last follow-up. Maximum follow-up at time of analysis was 10.3 years. Regional recurrence is defined as the documented progression in pelvic lymph nodes. If discovered on image of the pelvis prompted by a biochemical failure, then the event date would be the date of documented biochemical failure.
Percentage of Participants With Distant Metastasis From randomization to last follow-up. Follow-up schedule: end of RT (2nd arm only), then every 3 months for a year, every 4 months for 4 years, then yearly. Maximum follow-up at time of analysis was 10.3 years. Five-year rates reported here. Distant metastasis (failure) is defined as metastatic disease documented by any method. If diagnosed on diagnostic imaging prompted by biochemical failure, then the event date will be the date of biochemical progression.
Failure time is defined as time from randomization to the date of first failure, last known follow-up (competing risk), or death without failure (censored). Failure rates are estimated using the cumulative incidence method. The protocol specifies that the distributions of failure times be compared between the arms, which is reported in the statistical analysis results. Five-year rates are provided here. Analysis was planned to occur after 218 deaths were reported.Percentage of Participants Dead Due to Prostate Cancer (Prostate Cancer-specific Mortality) From randomization to last follow-up. Follow-up schedule: end of RT (2nd arm only), then every 3 months for a year, every 4 months for 4 years, then yearly. Maximum follow-up at time of analysis was 10.3 years. Five-year rates reported here. Prostate cancer specific mortality (failure) is defined as death due to prostate cancer or a complication from treatment. Failure time is defined as time from randomization to the date of first failure, last known follow-up (censored), or death without failure (competing risk). Failure rates are estimated using the cumulative incidence method. The protocol specifies that the distributions of failure times be compared between the arms, which is reported in the statistical analysis results. Five-year rates are provided here. Analysis was planned to occur after 218 deaths were reported.
Percentage of Participants Dead Due to Cause Other Than Prostate Cancer (Non-Prostate Cancer-specific Mortality) From randomization to last follow-up. Follow-up schedule: end of RT (2nd arm only), then every 3 months for a year, every 4 months for 4 years, then yearly. Maximum follow-up at time of analysis was 10.3 years. Five-year rates reported here. Non-prostate cancer specific mortality is defined as a death without evidence of prostate cancer or a complication from treatment. . Failure time is defined as time from randomization to the date of first failure, last known follow-up (censored), or death without failure (competing risk). Failure rates are estimated using the cumulative incidence method. The protocol specifies that the distributions of failure times be compared between the arms, which is reported in the statistical analysis results. Five-year rates are provided here. Analysis was planned to occur after 218 deaths were reported.
Percentage of Participants Receiving Salvage Androgen Deprivation Therapy (ADT) From randomization to last follow-up. Follow-up schedule: end of RT (2nd arm only), then every 3 months for a year, every 4 months for 4 years, then yearly. Maximum follow-up at time of analysis was 10.3 years. Five-year rates reported here. Salvage (non-protocol) ADT administration is defined as the first administration of subsequent ADT (either LHRH agonist or anti-androgen) Failure time is defined as time from randomization to the date of first failure, last known follow-up (censored), or death without failure (competing risk). Salvage ADT rates are estimated using the cumulative incidence method. The protocol specifies that the distributions of salvage ADT times be compared between the arms, which is reported in the statistical analysis results. Five-year rates are provided here. Analysis was planned to occur after 218 deaths were reported.
Percentage of Participants Alive (Overall Survival) by Radiation Therapy Modality From randomization to last follow-up. Follow-up schedule: end of RT (2nd arm only), then every 3 months for a year, every 4 months for 4 years, then yearly. Maximum follow-up at time of analysis was 10.3 years. Five-year rates reported here. Overall survival time is defined as time from randomization to the date of death from any cause or last known follow-up (censored). Overall survival rates are estimated by the Kaplan-Meier method. Five-year rates are provided here. Analysis was planned to occur after 218 deaths were reported.
Number of Participants With Acute Adverse Events From randomization to last follow-up. Follow-up schedule: end of RT (2nd arm only), then every 3 months for a year, every 4 months for 4 years, then yearly. Maximum follow-up at time of analysis was 10.3 years. Summary data is provided in this outcome measure; see Adverse Events Module for specific adverse event data. Acute adverse events are defined as occuring within 30 days of completion of radiation therapy.
Percentage of Participants With Late Grade 3+ Adverse Events From randomization to last follow-up. Follow-up schedule: end of RT (2nd arm only), then every 3 months for a year, every 4 months for 4 years, then yearly. Maximum follow-up at time of analysis was 10.3 years. Five-year rates are reported here. Common Terminology Criteria for Adverse Events (version 4.0) grades adverse event severity from 1=mild to 5=death. Summary data is provided in this outcome measure; see Adverse Events Module for specific adverse event data. Late adverse events are defined as occurring more than 30 days after the end of radiation therapy. Failure is defined as grade 3 or higher late adverse event. Failure time is defined as time from randomization to the date of first failure, last known follow-up (censored), or death without failure (competing risk). Failure rates are estimated using the cumulative incidence method. The protocol specifies that the distributions of failure times be compared between the arms, which is reported in the statistical analysis results. Five-year rates are provided here. Analysis was planned to occur after 218 deaths were reported.
Percentage of Participants Failed (Freedom From Failure) From randomization to last follow-up. Follow-up schedule: end of RT (2nd arm only), then every 3 months for a year, every 4 months for 4 years, then yearly. Maximum follow-up at time of analysis was 10.3 years. Five-year rates are reported here. Failure is defined as biochemical failure, local failure, or distant metastasis. Failure time is defined as time from randomization to the date of first failure, last known follow-up (censored), or death without failure (competing risk). Failure rates are estimated using the cumulative incidence method. The protocol specifies that the distributions of failure times be compared between the arms, which is reported in the statistical analysis results. Five-year rates are provided here. Analysis was planned to occur after 218 deaths were reported.
Change From Baseline in Expanded Prostate Cancer Index Composite (EPIC) Urinary Domain Score Last week of RT (approximately 9 and 17 weeks from start of protocol treatment for Arm 1 and 2, respectively), then 6 months, 1 year and 5 years from end of RT. The EPIC assesses disease-specific aspects of prostate cancer and it's therapies and consists of four summary domains (bowel, urinary, sexual, and hormonal), each ranging from 0-100, with higher scores representing better health-related quality of life. Change is calculated as time point value - baseline value, such that a positive change indicates improvement.
Change From Baseline in Expanded Prostate Cancer Index Composite (EPIC) Bowel Domain Score Last week of RT (approximately 9 and 17 weeks from start of protocol treatment for Arm 1 and 2, respectively), then 6 months, 1 year and 5 years from end of RT. The EPIC assesses disease-specific aspects of prostate cancer and it's therapies and consists of four summary domains (bowel, urinary, sexual, and hormonal), each ranging from 0-100, with higher scores representing better health-related quality of life. Change is calculated as time point value - baseline value, such that a positive change indicates improvement.
Change From Baseline in Expanded Prostate Cancer Index Composite (EPIC) Hormonal Domain Score Last week of RT (approximately 9 and 17 weeks from start of protocol treatment for Arm 1 and 2, respectively), then 6 months, 1 year and 5 years from end of RT. The EPIC assesses disease-specific aspects of prostate cancer and it's therapies and consists of four summary domains (bowel, urinary, sexual, and hormonal), each ranging from 0-100, with higher scores representing better health-related quality of life. Change is calculated as time point value - baseline value, such that a positive change indicates improvement.
Change From Baseline in Expanded Prostate Cancer Index Composite (EPIC) Sexual Domain Score Last week of RT (approximately 9 and 17 weeks from start of protocol treatment for Arm 1 and 2, respectively), then 6 months, 1 year and 5 years from end of RT. The EPIC assesses disease-specific aspects of prostate cancer and it's therapies and consists of four summary domains (bowel, urinary, sexual, and hormonal), each ranging from 0-100, with higher scores representing better health-related quality of life. Change is calculated as time point value - baseline value, such that a positive change indicates improvement.
Change From Baseline in Patient Reported Outcome Measurement Information System (PROMIS) Fatigue Domain Score Last week of RT (approximately 9 and 17 weeks from start of protocol treatment for Arm 1 and 2, respectively), then 6 months, 1 year and 5 years from end of RT. The PROMIS Fatigue short form 8a contains 8 questions, each with 5 responses ranging from 1 to 5, evaluating self-reported fatigue symptoms over the past 7 days. The total score is the sum of all questions which is then converted into a pro-rated T-score with a mean of 50 and standard deviation of 10, with a possible range of 33.1 to 77.8. Higher scores indicate more fatigue. Change is defined as value at one year - value at baseline. Positive change from baseline indicates increased fatigue at one year.
Trial Locations
- Locations (517)
Northside Hospital
🇺🇸Atlanta, Georgia, United States
Ohio State University Comprehensive Cancer Center
🇺🇸Columbus, Ohio, United States
Riverside Methodist Hospital
🇺🇸Columbus, Ohio, United States
Grant Medical Center
🇺🇸Columbus, Ohio, United States
The Mark H Zangmeister Center
🇺🇸Columbus, Ohio, United States
Mount Carmel Health Center West
🇺🇸Columbus, Ohio, United States
Doctors Hospital
🇺🇸Columbus, Ohio, United States
Texas Cancer Center - Medical City Dallas
🇺🇸Dallas, Texas, United States
UT Southwestern/Simmons Cancer Center-Dallas
🇺🇸Dallas, Texas, United States
John H Stroger Jr Hospital of Cook County
🇺🇸Chicago, Illinois, United States
Advocate Illinois Masonic Medical Center
🇺🇸Chicago, Illinois, United States
Case Western Reserve University
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic Cancer Center/Fairview Hospital
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
Virginia Mason CCOP
🇺🇸Seattle, Washington, United States
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States
Memorial Hermann Memorial City Medical Center
🇺🇸Houston, Texas, United States
M D Anderson Cancer Center
🇺🇸Houston, Texas, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
🇺🇸Miami, Florida, United States
IU Health Methodist Hospital
🇺🇸Indianapolis, Indiana, United States
IU Health Central Indiana Cancer Centers-East
🇺🇸Indianapolis, Indiana, United States
Kaiser Permanente-Redwood City
🇺🇸Redwood City, California, United States
Kaiser Permanente-Santa Teresa-San Jose
🇺🇸San Jose, California, United States
University of California San Diego
🇺🇸San Diego, California, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Columbus CCOP
🇺🇸Columbus, Ohio, United States
Kaiser Permanente-San Francisco
🇺🇸San Francisco, California, United States
UCSF Medical Center-Mount Zion
🇺🇸San Francisco, California, United States
California Pacific Medical Center-Pacific Campus
🇺🇸San Francisco, California, United States
Utah Cancer Specialists-Salt Lake City
🇺🇸Salt Lake City, Utah, United States
LDS Hospital
🇺🇸Salt Lake City, Utah, United States
Lawrence Memorial Hospital
🇺🇸Lawrence, Kansas, United States
Mid Dakota Clinic
🇺🇸Bismarck, North Dakota, United States
Trinity Cancer Care Center
🇺🇸Minot, North Dakota, United States
Saint Alexius Medical Center
🇺🇸Bismarck, North Dakota, United States
Cancer Center of Kansas-Wichita Medical Arts Tower
🇺🇸Wichita, Kansas, United States
Via Christi Regional Medical Center
🇺🇸Wichita, Kansas, United States
Cancer Center of Kansas - Winfield
🇺🇸Winfield, Kansas, United States
Cancer Center of Kansas - Main Office
🇺🇸Wichita, Kansas, United States
Sanford Medical Center-Fargo
🇺🇸Fargo, North Dakota, United States
Welch Cancer Center
🇺🇸Sheridan, Wyoming, United States
Sanford Bismarck Medical Center
🇺🇸Bismarck, North Dakota, United States
Baystate Medical Center
🇺🇸Springfield, Massachusetts, United States
Boston Medical Center
🇺🇸Boston, Massachusetts, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Abington Memorial Hospital
🇺🇸Abington, Pennsylvania, United States
Newark Beth Israel Medical Center
🇺🇸Newark, New Jersey, United States
University of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
Saint Elizabeth Regional Medical Center
🇺🇸Lincoln, Nebraska, United States
Kootenai Cancer Center
🇺🇸Post Falls, Idaho, United States
Maine Medical Center- Scarborough Campus
🇺🇸Scarborough, Maine, United States
Princeton Radiation Oncology Center
🇺🇸Monroe, New Jersey, United States
21st Century Oncology-Scottsdale
🇺🇸Scottsdale, Arizona, United States
Mayo Clinic in Arizona
🇺🇸Scottsdale, Arizona, United States
Helen F Graham Cancer Center
🇺🇸Newark, Delaware, United States
Idaho Urologic Institute-Meridian
🇺🇸Meridian, Idaho, United States
Dartmouth Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
UMDNJ - New Jersey Medical School
🇺🇸Newark, New Jersey, United States
Mercy Cancer Center-Hot Springs
🇺🇸Hot Springs, Arkansas, United States
Concord Hospital
🇺🇸Concord, New Hampshire, United States
Saint Joseph's Hospital and Medical Center
🇺🇸Phoenix, Arizona, United States
Arizona Oncology Services Foundation
🇺🇸Scottsdale, Arizona, United States
Arizona Oncology Associates-West Orange Grove
🇺🇸Tucson, Arizona, United States
Fairbanks Memorial Hospital
🇺🇸Fairbanks, Alaska, United States
Arizona Center for Cancer Care-Peoria
🇺🇸Peoria, Arizona, United States
Montana Cancer Consortium CCOP
🇺🇸Billings, Montana, United States
Christiana Care Health System-Christiana Hospital
🇺🇸Newark, Delaware, United States
Midstate Medical Center
🇺🇸Meriden, Connecticut, United States
The Hospital of Central Connecticut
🇺🇸New Britain, Connecticut, United States
Hartford Hospital
🇺🇸Hartford, Connecticut, United States
Saint Francis Hospital and Medical Center
🇺🇸Hartford, Connecticut, United States
Berdeaux, Donald MD (UIA Investigator)
🇺🇸Great Falls, Montana, United States
University of Alabama at Birmingham Cancer Center
🇺🇸Birmingham, Alabama, United States
The Urology Center of Colorado
🇺🇸Denver, Colorado, United States
Northern Rockies Radiation Oncology Center
🇺🇸Billings, Montana, United States
Great Falls Clinic
🇺🇸Great Falls, Montana, United States
Cooper Hospital University Medical Center
🇺🇸Camden, New Jersey, United States
Ocean Medical Center
🇺🇸Brick, New Jersey, United States
Prostate Cancer Center of New Jersey
🇺🇸West Orange, New Jersey, United States
Virtua West Jersey Hospital Voorhees
🇺🇸Voorhees, New Jersey, United States
Greenville Health System Cancer Institute-Faris
🇺🇸Greenville, South Carolina, United States
Cheshire Medical Center-Dartmouth-Hitchcock Keene
🇺🇸Keene, New Hampshire, United States
Jersey Shore Medical Center
🇺🇸Neptune, New Jersey, United States
Southwestern Vermont Medical Center
🇺🇸Bennington, Vermont, United States
McGill University Department of Oncology
🇨🇦Montreal, Quebec, Canada
Norris Cotton Cancer Center-North
🇺🇸Saint Johnsbury, Vermont, United States
Elliot Hospital
🇺🇸Manchester, New Hampshire, United States
University of Cincinnati
🇺🇸Cincinnati, Ohio, United States
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County
🇺🇸Mount Holly, New Jersey, United States
Community Medical Center
🇺🇸Toms River, New Jersey, United States
The Medical Center At Princeton
🇺🇸Princeton, New Jersey, United States
UMDNJ - Robert Wood Johnson University Hospital
🇺🇸New Brunswick, New Jersey, United States
Tom Baker Cancer Centre
🇨🇦Calgary, Alberta, Canada
Greenville Health System Cancer Institute-Greer
🇺🇸Greer, South Carolina, United States
MD Anderson Cancer Center at Cooper-Voorhees
🇺🇸Voorhees, New Jersey, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
Saint John Hospital and Medical Center
🇺🇸Detroit, Michigan, United States
Gibbs Cancer Center-Pelham
🇺🇸Greer, South Carolina, United States
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Greenville Health System Cancer Institute-Seneca
🇺🇸Seneca, South Carolina, United States
Blount Memorial Hospital
🇺🇸Maryville, Tennessee, United States
QEII Health Sciences Centre/Capital District Health Authority
🇨🇦Halifax, Nova Scotia, Canada
Rapid City Regional Hospital
🇺🇸Rapid City, South Dakota, United States
Wellmont Holston Valley Hospital and Medical Center
🇺🇸Kingsport, Tennessee, United States
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
🇨🇦Quebec City, Quebec, Canada
Thompson Cancer Survival Center
🇺🇸Knoxville, Tennessee, United States
Providence Portland Medical Center
🇺🇸Portland, Oregon, United States
Western Oncology Research Consortium
🇺🇸Portland, Oregon, United States
Providence Saint Vincent Medical Center
🇺🇸Portland, Oregon, United States
Rutland Regional Medical Center
🇺🇸Rutland, Vermont, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Missouri Valley Cancer Consortium
🇺🇸Omaha, Nebraska, United States
Nebraska Methodist Hospital
🇺🇸Omaha, Nebraska, United States
Alegent Health Immanuel Medical Center
🇺🇸Omaha, Nebraska, United States
Alegent Health Bergan Mercy Medical Center
🇺🇸Omaha, Nebraska, United States
Alegent Health Lakeside Hospital
🇺🇸Omaha, Nebraska, United States
Creighton University Medical Center
🇺🇸Omaha, Nebraska, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Columbia Saint Mary's Water Tower Medical Commons
🇺🇸Milwaukee, Wisconsin, United States
Froedtert and the Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Zablocki Veterans Administration Medical Center
🇺🇸Milwaukee, Wisconsin, United States
Mercy Hospital Springfield
🇺🇸Springfield, Missouri, United States
North Shore University Hospital
🇺🇸Manhasset, New York, United States
West Texas Cancer Center
🇺🇸Odessa, Texas, United States
University of Colorado Cancer Center - Anschutz Cancer Pavilion
🇺🇸Aurora, Colorado, United States
James A. Haley Veterans Affairs Hospital
🇺🇸Tampa, Florida, United States
Rocky Mountain Cancer Centers-Aurora
🇺🇸Aurora, Colorado, United States
Walter Reed National Military Medical Center
🇺🇸Bethesda, Maryland, United States
Sutter General Hospital
🇺🇸Sacramento, California, United States
University of California Davis Comprehensive Cancer Center
🇺🇸Sacramento, California, United States
Mercy General Hospital Radiation Oncology Center
🇺🇸Sacramento, California, United States
Kaiser Permanente-South Sacramento
🇺🇸Sacramento, California, United States
South Sacramento Cancer Center
🇺🇸Sacramento, California, United States
University of Michigan Comprehensive Cancer Center
🇺🇸Ann Arbor, Michigan, United States
Southeast Cancer Consortium-Upstate NCORP
🇺🇸Winston-Salem, North Carolina, United States
Yale-New Haven Hospital Saint Raphael Campus
🇺🇸New Haven, Connecticut, United States
Florida Hospital Orlando
🇺🇸Orlando, Florida, United States
The James Graham Brown Cancer Center at University of Louisville
🇺🇸Louisville, Kentucky, United States
Alta Bates Summit Medical Center-Herrick Campus
🇺🇸Berkeley, California, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn
🇺🇸Auburn, California, United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
🇺🇸Cameron Park, California, United States
Mercy San Juan Medical Center
🇺🇸Carmichael, California, United States
Enloe Medical Center
🇺🇸Chico, California, United States
21st Century Oncology - El Segundo
🇺🇸El Segundo, California, United States
Fresno Cancer Center
🇺🇸Fresno, California, United States
Marin General Hospital
🇺🇸Greenbrae, California, United States
USC / Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Los Angeles County-USC Medical Center
🇺🇸Los Angeles, California, United States
Memorial Medical Center
🇺🇸Springfield, Illinois, United States
Desert Regional Medical Center
🇺🇸Palm Springs, California, United States
Kaiser Permanente-Oakland
🇺🇸Oakland, California, United States
Kaiser Permanente Oakland-Broadway
🇺🇸Oakland, California, United States
Stanford Cancer Institute
🇺🇸Palo Alto, California, United States
Feather River Cancer Center
🇺🇸Paradise, California, United States
Pomona Valley Hospital Medical Center
🇺🇸Pomona, California, United States
Kaiser Permanente-Rancho Cordova Cancer Center
🇺🇸Rancho Cordova, California, United States
Kaiser Permanente-Richmond
🇺🇸Richmond, California, United States
Kaiser Permanente-Roseville
🇺🇸Roseville, California, United States
Rohnert Park Cancer Center
🇺🇸Rohnert Park, California, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville
🇺🇸Roseville, California, United States
The Permanente Medical Group-Roseville Radiation Oncology
🇺🇸Roseville, California, United States
Kaiser Permanente - Sacramento
🇺🇸Sacramento, California, United States
Kaiser Permanente San Leandro
🇺🇸San Leandro, California, United States
Kaiser Permanente-San Rafael
🇺🇸San Rafael, California, United States
Kaiser Permanente Medical Center - Santa Clara
🇺🇸Santa Clara, California, United States
Kaiser Permanente-South San Francisco
🇺🇸South San Francisco, California, United States
Kaiser Permanente Cancer Treatment Center
🇺🇸South San Francisco, California, United States
Kaiser Permanente-Stockton
🇺🇸Stockton, California, United States
David Grant United States Air Force Medical Center
🇺🇸Travis Air Force Base, California, United States
Tahoe Forest Cancer Center
🇺🇸Truckee, California, United States
Sutter Solano Medical Center/Cancer Center
🇺🇸Vallejo, California, United States
Kaiser Permanente-Walnut Creek
🇺🇸Walnut Creek, California, United States
Poudre Valley Hospital
🇺🇸Fort Collins, Colorado, United States
The Shaw Regional Cancer Center
🇺🇸Edwards, Colorado, United States
Saint Mary's Hospital and Regional Medical Center
🇺🇸Grand Junction, Colorado, United States
Florida Hospital Kissimmee
🇺🇸Kissimmee, Florida, United States
Lakeland Regional Cancer Center
🇺🇸Lakeland, Florida, United States
The Watson Clinic
🇺🇸Lakeland, Florida, United States
Jackson Memorial Hospital-Holtz Children's Hospital
🇺🇸Miami, Florida, United States
South Miami Hospital
🇺🇸Miami, Florida, United States
Bay Medical Center
🇺🇸Panama City, Florida, United States
Piedmont Hospital
🇺🇸Atlanta, Georgia, United States
Emory University/Winship Cancer Institute
🇺🇸Atlanta, Georgia, United States
Grady Health System
🇺🇸Atlanta, Georgia, United States
Northside Hospital-Forsyth
🇺🇸Cumming, Georgia, United States
Memorial University Medical Center
🇺🇸Savannah, Georgia, United States
Northeast Georgia Medical Center
🇺🇸Gainesville, Georgia, United States
John B Amos Cancer Center
🇺🇸Columbus, Georgia, United States
Piedmont Fayette Hospital
🇺🇸Fayetteville, Georgia, United States
Saint Anthony's Health
🇺🇸Alton, Illinois, United States
Northwestern University
🇺🇸Chicago, Illinois, United States
Memorial Hospital of Carbondale
🇺🇸Carbondale, Illinois, United States
University of Chicago Comprehensive Cancer Center
🇺🇸Chicago, Illinois, United States
Crossroads Cancer Center
🇺🇸Effingham, Illinois, United States
Hines Veterans Administration Hospital
🇺🇸Hines, Illinois, United States
Pekin Cancer Treatment Center
🇺🇸Pekin, Illinois, United States
OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
🇺🇸Peoria, Illinois, United States
Loyola University Medical Center
🇺🇸Maywood, Illinois, United States
SwedishAmerican Regional Cancer Center/ACT
🇺🇸Rockford, Illinois, United States
OSF Saint Francis Medical Center
🇺🇸Peoria, Illinois, United States
Memorial and Saint Elizabeth's Health Care Services LLP
🇺🇸Swansea, Illinois, United States
Saint John's Hospital
🇺🇸Springfield, Illinois, United States
Saint Vincent Anderson Regional Hospital/Cancer Center
🇺🇸Anderson, Indiana, United States
IU Health West Hospital
🇺🇸Avon, Indiana, United States
IU Health Bloomington
🇺🇸Bloomington, Indiana, United States
IU Health Goshen Center for Cancer Care
🇺🇸Goshen, Indiana, United States
Radiation Oncology Associates PC
🇺🇸Fort Wayne, Indiana, United States
Parkview Hospital Randallia
🇺🇸Fort Wayne, Indiana, United States
Indiana University/Melvin and Bren Simon Cancer Center
🇺🇸Indianapolis, Indiana, United States
Richard L. Roudebush Veterans Affairs Medical Center
🇺🇸Indianapolis, Indiana, United States
McFarland Clinic PC-William R Bliss Cancer Center
🇺🇸Ames, Iowa, United States
Medical Oncology and Hematology Associates-West Des Moines
🇺🇸Clive, Iowa, United States
Finley Hospital
🇺🇸Dubuque, Iowa, United States
Associates In Womens Health
🇺🇸Wichita, Kansas, United States
Cancer Center of Kansas - El Dorado
🇺🇸El Dorado, Kansas, United States
Cancer Center of Kansas - Dodge City
🇺🇸Dodge City, Kansas, United States
Cancer Center of Kansas - Wellington
🇺🇸Wellington, Kansas, United States
Kansas City Cancer Centers-Southwest
🇺🇸Overland Park, Kansas, United States
Wichita CCOP
🇺🇸Wichita, Kansas, United States
Owensboro Health Mitchell Memorial Cancer Center
🇺🇸Owensboro, Kentucky, United States
Central Maine Medical Center
🇺🇸Lewiston, Maine, United States
Anne Arundel Medical Center
🇺🇸Annapolis, Maryland, United States
University of Maryland/Greenebaum Cancer Center
🇺🇸Baltimore, Maryland, United States
Central Maryland Radiation Oncology in Howard County
🇺🇸Columbia, Maryland, United States
Saint Agnes Hospital
🇺🇸Baltimore, Maryland, United States
Greater Baltimore Medical Center
🇺🇸Baltimore, Maryland, United States
Upper Chesapeake Medical Center
🇺🇸Bel Air, Maryland, United States
Tate Cancer Center
🇺🇸Glen Burnie, Maryland, United States
Holy Cross Hospital
🇺🇸Silver Spring, Maryland, United States
Massachusetts General Hospital Cancer Center
🇺🇸Boston, Massachusetts, United States
Mass General/North Shore Cancer Center
🇺🇸Danvers, Massachusetts, United States
Cape Cod Hospital
🇺🇸Hyannis, Massachusetts, United States
Saint Anne's Hospital
🇺🇸Fall River, Massachusetts, United States
Lowell General Hospital
🇺🇸Lowell, Massachusetts, United States
Berkshire Hematology Oncology PC
🇺🇸Pittsfield, Massachusetts, United States
Beth Israel Deaconess Hospital-Plymouth
🇺🇸Plymouth, Massachusetts, United States
D'Amour Center for Cancer Care
🇺🇸Springfield, Massachusetts, United States
Saint Vincent Hospital/Reliant Medical Group
🇺🇸Worcester, Massachusetts, United States
Bixby Medical Center
🇺🇸Adrian, Michigan, United States
Veteran's Administration Medical Center - Ann Arbor
🇺🇸Ann Arbor, Michigan, United States
Bronson Battle Creek
🇺🇸Battle Creek, Michigan, United States
Saint Joseph Mercy Hospital
🇺🇸Ann Arbor, Michigan, United States
McLaren-Bay Region
🇺🇸Bay City, Michigan, United States
Henry Ford Macomb Hospital
🇺🇸Clinton Township, Michigan, United States
Huron Valley-Sinai Hospital
🇺🇸Commerce, Michigan, United States
Green Bay Oncology - Escanaba
🇺🇸Escanaba, Michigan, United States
McLaren-Flint
🇺🇸Flint, Michigan, United States
21st Century Oncology-Farmington Hills
🇺🇸Farmington Hills, Michigan, United States
Botsford General Hospital
🇺🇸Farmington, Michigan, United States
Genesys Regional Medical Center-West Flint Campus
🇺🇸Flint, Michigan, United States
Genesys Hurley Cancer Institute
🇺🇸Flint, Michigan, United States
Mercy Health Saint Mary's
🇺🇸Grand Rapids, Michigan, United States
Green Bay Oncology - Iron Mountain
🇺🇸Iron Mountain, Michigan, United States
Spectrum Health at Butterworth Campus
🇺🇸Grand Rapids, Michigan, United States
Borgess Medical Center
🇺🇸Kalamazoo, Michigan, United States
McLaren-Macomb
🇺🇸Mount Clemens, Michigan, United States
Bronson Methodist Hospital
🇺🇸Kalamazoo, Michigan, United States
West Michigan Cancer Center
🇺🇸Kalamazoo, Michigan, United States
Great Lakes Cancer Institute-Lapeer Campus
🇺🇸Lapeer, Michigan, United States
McLaren-Central Michigan
🇺🇸Mount Pleasant, Michigan, United States
Sparrow Hospital
🇺🇸Lansing, Michigan, United States
Mercy Health Mercy Campus
🇺🇸Muskegon, Michigan, United States
Northern Michigan Regional Hospital
🇺🇸Petoskey, Michigan, United States
McLaren Cancer Institute-Owosso
🇺🇸Owosso, Michigan, United States
Saint Joseph Mercy Oakland
🇺🇸Pontiac, Michigan, United States
Crittenton Hospital
🇺🇸Rochester, Michigan, United States
Saint Joseph Mercy Port Huron
🇺🇸Port Huron, Michigan, United States
William Beaumont Hospital-Royal Oak
🇺🇸Royal Oak, Michigan, United States
Saint Mary's of Michigan
🇺🇸Saginaw, Michigan, United States
21st Century Oncology-Troy
🇺🇸Troy, Michigan, United States
Downriver Center for Oncology
🇺🇸Trenton, Michigan, United States
William Beaumont Hospital - Troy
🇺🇸Troy, Michigan, United States
Saint John Macomb-Oakland Hospital
🇺🇸Warren, Michigan, United States
Miller-Dwan Hospital
🇺🇸Duluth, Minnesota, United States
Mayo Clinic Health System in Albert Lea
🇺🇸Albert Lea, Minnesota, United States
Henry Ford West Bloomfield Hospital
🇺🇸West Bloomfield, Michigan, United States
Sanford Clinic North-Bemidgi
🇺🇸Bemidji, Minnesota, United States
Saint Luke's Hospital of Duluth
🇺🇸Duluth, Minnesota, United States
Regions Hospital
🇺🇸Saint Paul, Minnesota, United States
Fairview-Southdale Hospital
🇺🇸Edina, Minnesota, United States
Mayo Clinic Health Systems-Mankato
🇺🇸Mankato, Minnesota, United States
Saint Francis Medical Center
🇺🇸Cape Girardeau, Missouri, United States
Mercy Hospital-Joplin
🇺🇸Joplin, Missouri, United States
Phelps County Regional Medical Center
🇺🇸Rolla, Missouri, United States
Kansas City Cancer Center-Lee's Summit
🇺🇸Lee's Summit, Missouri, United States
Siteman Cancer Center-South County
🇺🇸Saint Louis, Missouri, United States
Missouri Baptist Medical Center
🇺🇸Saint Louis, Missouri, United States
Mercy Hospital Saint Louis
🇺🇸Saint Louis, Missouri, United States
Barnes-Jewish West County Hospital
🇺🇸Saint Louis, Missouri, United States
Saint Louis-Cape Girardeau CCOP
🇺🇸Saint Louis, Missouri, United States
Siteman Cancer Center - Saint Peters
🇺🇸Saint Peters, Missouri, United States
CoxHealth South Hospital
🇺🇸Springfield, Missouri, United States
Billings Clinic Cancer Center
🇺🇸Billings, Montana, United States
Exeter Hospital
🇺🇸Exeter, New Hampshire, United States
Veterans Adminstration New Jersey Health Care System
🇺🇸East Orange, New Jersey, United States
Rutgers Cancer Institute of New Jersey
🇺🇸New Brunswick, New Jersey, United States
Sparta Cancer Treatment Center
🇺🇸Sparta, New Jersey, United States
Riverview Medical Center/Booker Cancer Center
🇺🇸Red Bank, New Jersey, United States
Memorial Medical Center - Las Cruces
🇺🇸Las Cruces, New Mexico, United States
Saint Peters Hospital-Albany
🇺🇸Albany, New York, United States
New York Oncology Hematology PC - Albany
🇺🇸Albany, New York, United States
Southside Hospital
🇺🇸Bay Shore, New York, United States
State University of New York Downstate Medical Center
🇺🇸Brooklyn, New York, United States
Lourdes Hospital
🇺🇸Binghamton, New York, United States
Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
🇺🇸Brooklyn, New York, United States
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
Arnot Ogden Medical Center/Falck Cancer Center
🇺🇸Elmira, New York, United States
North Shore-LIJ Health System NCORP
🇺🇸Manhasset, New York, United States
Long Island Jewish Medical Center
🇺🇸New Hyde Park, New York, United States
North Shore-LIJ Health System/Center for Advanced Medicine
🇺🇸New Hyde Park, New York, United States
Hudson Valley Oncology Associates
🇺🇸Poughkeepsie, New York, United States
Columbia University Medical Center
🇺🇸New York, New York, United States
Cone Health Cancer Center
🇺🇸Greensboro, North Carolina, United States
Randolph Hospital
🇺🇸Asheboro, North Carolina, United States
Mary Imogene Bassett Hospital
🇺🇸Cooperstown, New York, United States
Sands Cancer Center
🇺🇸Canandaigua, New York, United States
South Atlantic Radiation Oncology
🇺🇸Supply, North Carolina, United States
Rex Cancer Center
🇺🇸Raleigh, North Carolina, United States
The Coleman Radiation Center-Carteret General Hospital
🇺🇸Morehead City, North Carolina, United States
CarolinaEast Health System-Medical Center
🇺🇸New Bern, North Carolina, United States
Duke Cancer Institute Macon Pond
🇺🇸Raleigh, North Carolina, United States
New Hanover Regional Medical Center/Zimmer Cancer Center
🇺🇸Wilmington, North Carolina, United States
Coastal Carolina Radiation Oncology
🇺🇸Wilmington, North Carolina, United States
Summa Akron City Hospital/Cooper Cancer Center
🇺🇸Akron, Ohio, United States
Sanford Clinic North-Fargo
🇺🇸Fargo, North Dakota, United States
Akron General Medical Center
🇺🇸Akron, Ohio, United States
Summa Barberton Hospital
🇺🇸Barberton, Ohio, United States
Geaugra Hospital
🇺🇸Chardon, Ohio, United States
UHHS-Chagrin Highlands Medical Center
🇺🇸Beachwood, Ohio, United States
Adena Regional Medical Center
🇺🇸Chillicothe, Ohio, United States
Grady Memorial Hospital
🇺🇸Delaware, Ohio, United States
Toledo Clinic Cancer Centers-Maumee
🇺🇸Maumee, Ohio, United States
Mercy Cancer Center-Elyria
🇺🇸Elyria, Ohio, United States
Marietta Memorial Hospital
🇺🇸Marietta, Ohio, United States
Cleveland Clinic Cancer Center Independence
🇺🇸Independence, Ohio, United States
Hillcrest Hospital Cancer Center
🇺🇸Mayfield Heights, Ohio, United States
Lake University Ireland Cancer Center
🇺🇸Mentor, Ohio, United States
Southwest General Health Center Ireland Cancer Center
🇺🇸Middleburg Heights, Ohio, United States
Southern Ohio Medical Center
🇺🇸Portsmouth, Ohio, United States
University Hospitals Parma Medical Center
🇺🇸Parma, Ohio, United States
Summa Health Center at Lake Medina
🇺🇸Medina, Ohio, United States
Saint Charles Hospital
🇺🇸Oregon, Ohio, United States
Licking Memorial Hospital
🇺🇸Newark, Ohio, United States
Cancer Care Center, Incorporated
🇺🇸Salem, Ohio, United States
Robinson Radiation Oncology
🇺🇸Ravenna, Ohio, United States
North Coast Cancer Care
🇺🇸Sandusky, Ohio, United States
Ireland Cancer Center at Firelands Regional Medical Center
🇺🇸Sandusky, Ohio, United States
Flower Hospital
🇺🇸Sylvania, Ohio, United States
University of Toledo
🇺🇸Toledo, Ohio, United States
Mercy Saint Anne Hospital
🇺🇸Toledo, Ohio, United States
Saint Ann's Hospital
🇺🇸Westerville, Ohio, United States
Genesis HealthCare System
🇺🇸Zanesville, Ohio, United States
University Pointe
🇺🇸West Chester, Ohio, United States
UHHS-Westlake Medical Center
🇺🇸Westlake, Ohio, United States
Cleveland Clinic Wooster Specialty Center
🇺🇸Wooster, Ohio, United States
Cancer Treatment Center
🇺🇸Wooster, Ohio, United States
Willamette Valley Cancer Center
🇺🇸Eugene, Oregon, United States
Wright-Patterson Medical Center
🇺🇸Wright-Patterson Air Force Base, Ohio, United States
Clackamas Radiation Oncology Center
🇺🇸Clackamas, Oregon, United States
Legacy Mount Hood Medical Center
🇺🇸Gresham, Oregon, United States
Asante Health System
🇺🇸Medford, Oregon, United States
Providence Medford Medical Center
🇺🇸Medford, Oregon, United States
Three Rivers Community Hospital
🇺🇸Grants Pass, Oregon, United States
Providence Milwaukie Hospital
🇺🇸Milwaukie, Oregon, United States
Legacy Good Samaritan Hospital and Medical Center
🇺🇸Portland, Oregon, United States
Saint Luke's University Hospital-Bethlehem Campus
🇺🇸Bethlehem, Pennsylvania, United States
Legacy Meridian Park Hospital
🇺🇸Tualatin, Oregon, United States
Bryn Mawr Hospital
🇺🇸Bryn Mawr, Pennsylvania, United States
Mercy Fitzgerald Hospital
🇺🇸Darby, Pennsylvania, United States
Geisinger Medical Center
🇺🇸Danville, Pennsylvania, United States
Delaware County Memorial Hospital
🇺🇸Drexel Hill, Pennsylvania, United States
Northeast Radiation Oncology Center
🇺🇸Dunmore, Pennsylvania, United States
The Regional Cancer Center
🇺🇸Erie, Pennsylvania, United States
Fox Chase Cancer Center Buckingham
🇺🇸Furlong, Pennsylvania, United States
Adams Cancer Center
🇺🇸Gettysburg, Pennsylvania, United States
Cherry Tree Cancer Center
🇺🇸Hanover, Pennsylvania, United States
Academic Urology Prostate Center
🇺🇸King Of Prussia, Pennsylvania, United States
Saint Mary Medical and Regional Cancer Center
🇺🇸Langhorne, Pennsylvania, United States
Upper Delaware Valley Cancer Center
🇺🇸Milford, Pennsylvania, United States
Thomas Jefferson University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Albert Einstein Medical Center
🇺🇸Philadelphia, Pennsylvania, United States
Paoli Memorial Hospital
🇺🇸Paoli, Pennsylvania, United States
Temple University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Reading Hospital
🇺🇸West Reading, Pennsylvania, United States
Lankenau Medical Center
🇺🇸Wynnewood, Pennsylvania, United States
Mainline Health CCOP
🇺🇸Wynnewood, Pennsylvania, United States
Greenville Health System Cancer Institute-Eastside
🇺🇸Greenville, South Carolina, United States
Self Regional Healthcare
🇺🇸Greenwood, South Carolina, United States
Greenville Health System Cancer Institute-Spartanburg
🇺🇸Spartanburg, South Carolina, United States
Carolina Regional Cancer Center
🇺🇸Myrtle Beach, South Carolina, United States
Texas Oncology Bedford
🇺🇸Bedford, Texas, United States
Texas Oncology-Denton South
🇺🇸Denton, Texas, United States
Texas Oncology Methodist Charlton Cancer Center
🇺🇸Dallas, Texas, United States
Brooke Army Medical Center
🇺🇸Fort Sam Houston, Texas, United States
University of Texas Medical Branch
🇺🇸Galveston, Texas, United States
The Klabzuba Cancer Center
🇺🇸Fort Worth, Texas, United States
UTMB Cancer Center at Victory Lakes
🇺🇸League City, Texas, United States
Texas Oncology - Lewisville
🇺🇸Lewisville, Texas, United States
Texas Oncology-Longview Cancer Center
🇺🇸Longview, Texas, United States
Texas Oncology-Seton Williamson
🇺🇸Round Rock, Texas, United States
Texas Oncology Cancer Center Sugar Land
🇺🇸Sugar Land, Texas, United States
Texas Cancer Center-Sherman
🇺🇸Sherman, Texas, United States
Texas Oncology-Wichita Falls Texoma Cancer Center
🇺🇸Wichita Falls, Texas, United States
Intermountain Medical Center
🇺🇸Murray, Utah, United States
Dixie Medical Center Regional Cancer Center
🇺🇸Saint George, Utah, United States
Texas Oncology - Round Rock Cancer Center
🇺🇸Round Rock, Texas, United States
Sandra L Maxwell Cancer Center
🇺🇸Cedar City, Utah, United States
Utah Valley Regional Medical Center
🇺🇸Provo, Utah, United States
Huntsman Cancer Institute/University of Utah
🇺🇸Salt Lake City, Utah, United States
Inova Alexandria Hospital
🇺🇸Alexandria, Virginia, United States
Danville Regional Medical Center
🇺🇸Danville, Virginia, United States
Augusta Health Cancer Center
🇺🇸Fishersville, Virginia, United States
Sentara Rockingham Memorial Hospital Hahn Cancer Center
🇺🇸Harrisonburg, Virginia, United States
Sentara Hospitals
🇺🇸Norfolk, Virginia, United States
Sentara Cancer Institute at Sentara CarePlex Hospital
🇺🇸Hampton, Virginia, United States
Naval Medical Center - Portsmouth
🇺🇸Portsmouth, Virginia, United States
Southwest VA Regional Cancer Center
🇺🇸Norton, Virginia, United States
Oncology and Hematology Associates of Southwest Virginia
🇺🇸Roanoke, Virginia, United States
PeaceHealth Saint Joseph Medical Center
🇺🇸Bellingham, Washington, United States
Saint Francis Hospital
🇺🇸Federal Way, Washington, United States
Sentara Virginia Beach General Hospital
🇺🇸Virginia Beach, Virginia, United States
Cancer Care Northwest - Spokane South
🇺🇸Spokane, Washington, United States
PeaceHealth Southwest Medical Center
🇺🇸Vancouver, Washington, United States
Cancer Care Northwest-North Spokane
🇺🇸Spokane, Washington, United States
Legacy Salmon Creek Hospital
🇺🇸Vancouver, Washington, United States
Compass Oncology Vancouver
🇺🇸Vancouver, Washington, United States
Appleton Medical Center
🇺🇸Appleton, Wisconsin, United States
Bellin Memorial Hospital
🇺🇸Green Bay, Wisconsin, United States
Green Bay Oncology Limited at Saint Mary's Hospital
🇺🇸Green Bay, Wisconsin, United States
UW Cancer Center Johnson Creek
🇺🇸Johnson Creek, Wisconsin, United States
Mayo Clinic Health System-Franciscan Healthcare
🇺🇸La Crosse, Wisconsin, United States
Bay Area Medical Center
🇺🇸Marinette, Wisconsin, United States
Gundersen Lutheran Medical Center
🇺🇸La Crosse, Wisconsin, United States
Vince Lombardi Cancer Clinic-Marinette
🇺🇸Marinette, Wisconsin, United States
Community Memorial Hospital
🇺🇸Menomonee Falls, Wisconsin, United States
Columbia Saint Mary's Hospital - Ozaukee
🇺🇸Mequon, Wisconsin, United States
Aurora Saint Luke's Medical Center
🇺🇸Milwaukee, Wisconsin, United States
Wheaton Franciscan Cancer Care - All Saints
🇺🇸Racine, Wisconsin, United States
Green Bay Oncology - Oconto Falls
🇺🇸Oconto Falls, Wisconsin, United States
Door County Cancer Center
🇺🇸Sturgeon Bay, Wisconsin, United States
Green Bay Oncology - Sturgeon Bay
🇺🇸Sturgeon Bay, Wisconsin, United States
The Alyce and Elmore Kraemer Cancer Care Center
🇺🇸West Bend, Wisconsin, United States
Aurora Medical Center in Summit
🇺🇸Summit, Wisconsin, United States
Riverview Hospital
🇺🇸Wisconsin Rapids, Wisconsin, United States
BCCA-Cancer Centre for the Southern Interior
🇨🇦Kelowna, British Columbia, Canada
Juravinski Cancer Centre at Hamilton Health Sciences
🇨🇦Hamilton, Ontario, Canada
London Regional Cancer Program
🇨🇦London, Ontario, Canada
Ottawa Health Research Institute-General Division
🇨🇦Ottawa, Ontario, Canada
Irving Greenberg Family Cancer Centre
🇨🇦Ottawa, Ontario, Canada
Odette Cancer Centre- Sunnybrook Health Sciences Centre
🇨🇦Toronto, Ontario, Canada
Hopital Maisonneuve-Rosemont
🇨🇦Montreal, Quebec, Canada
Thunder Bay Regional Health Science Centre
🇨🇦Thunder Bay, Ontario, Canada
CHUM - Hopital Notre-Dame
🇨🇦Montreal, Quebec, Canada
Saskatoon Cancer Centre
🇨🇦Saskatoon, Saskatchewan, Canada
Saint Alphonsus Cancer Care Center-Boise
🇺🇸Boise, Idaho, United States
Saint Agnes Medical Center
🇺🇸Fresno, California, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
🇺🇸Savannah, Georgia, United States
Broward Health Medical Center
🇺🇸Fort Lauderdale, Florida, United States
Decatur Memorial Hospital
🇺🇸Decatur, Illinois, United States
Cancer Research for the Ozarks NCORP
🇺🇸Springfield, Missouri, United States
Spartanburg Medical Center
🇺🇸Spartanburg, South Carolina, United States
Veterans Administration Long Beach Medical Center
🇺🇸Long Beach, California, United States
Aurora BayCare Medical Center
🇺🇸Green Bay, Wisconsin, United States
Green Bay Oncology at Saint Vincent Hospital
🇺🇸Green Bay, Wisconsin, United States
Saint Vincent Hospital
🇺🇸Green Bay, Wisconsin, United States
Saint Mary's Hospital
🇺🇸Green Bay, Wisconsin, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
🇺🇸Burbank, California, United States
University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach
🇺🇸Deerfield Beach, Florida, United States
Aurora West Allis Medical Center
🇺🇸West Allis, Wisconsin, United States
McKay-Dee Hospital Center
🇺🇸Ogden, Utah, United States
Rogue Valley Medical Center
🇺🇸Medford, Oregon, United States
WellSpan Health-York Hospital
🇺🇸York, Pennsylvania, United States
Vince Lombardi Cancer Clinic - Oshkosh
🇺🇸Oshkosh, Wisconsin, United States
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
🇨🇦Sherbrooke, Quebec, Canada
AnMed Health Hospital
🇺🇸Anderson, South Carolina, United States
Texas Oncology-Arlington South
🇺🇸Arlington, Texas, United States
BCCA-Vancouver Island Cancer Centre
🇨🇦Victoria, British Columbia, Canada
Atlantic Health Sciences Corporation-Saint John Regional Hospital
🇨🇦Saint John, New Brunswick, Canada
Allan Blair Cancer Centre
🇨🇦Regina, Saskatchewan, Canada
Mary Bird Perkins Cancer Center
🇺🇸Baton Rouge, Louisiana, United States
Penn State Milton S Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
Wesley Medical Center
🇺🇸Wichita, Kansas, United States
Atlanta VA Medical Center
🇺🇸Decatur, Georgia, United States
VA Pittsburgh Healthcare System
🇺🇸Pittsburgh, Pennsylvania, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Texas Oncology-Austin Midtown
🇺🇸Austin, Texas, United States
Texas Oncology - Central Austin Cancer Center
🇺🇸Austin, Texas, United States
Texas Oncology - South Austin Cancer Center
🇺🇸Austin, Texas, United States
Queen's Medical Center
🇺🇸Honolulu, Hawaii, United States
University of Hawaii Cancer Center
🇺🇸Honolulu, Hawaii, United States
The Cancer Center of Hawaii-Liliha
🇺🇸Honolulu, Hawaii, United States
Tulane University Health Sciences Center
🇺🇸New Orleans, Louisiana, United States
Ochsner Medical Center Jefferson
🇺🇸New Orleans, Louisiana, United States
Kansas City Cancer Center - South
🇺🇸Kansas City, Missouri, United States
Kansas City Cancer Centers - North
🇺🇸Kansas City, Missouri, United States
University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Iowa Methodist Medical Center
🇺🇸Des Moines, Iowa, United States
Iowa Oncology Research Association CCOP
🇺🇸Des Moines, Iowa, United States
Medical Oncology and Hematology Associates-Des Moines
🇺🇸Des Moines, Iowa, United States
Medical Oncology and Hematology Associates-Laurel
🇺🇸Des Moines, Iowa, United States
Mercy Medical Center - Des Moines
🇺🇸Des Moines, Iowa, United States
Iowa Lutheran Hospital
🇺🇸Des Moines, Iowa, United States
Baptist Health Lexington
🇺🇸Lexington, Kentucky, United States
University of Kentucky/Markey Cancer Center
🇺🇸Lexington, Kentucky, United States
Lovelace Medical Center-Downtown
🇺🇸Albuquerque, New Mexico, United States
University of New Mexico
🇺🇸Albuquerque, New Mexico, United States
University of New Mexico Cancer Center
🇺🇸Albuquerque, New Mexico, United States
Radiation Oncology Associates
🇺🇸Albuquerque, New Mexico, United States
Highland Hospital
🇺🇸Rochester, New York, United States
Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada
University Radiation Oncology
🇺🇸Rochester, New York, United States
University of Rochester
🇺🇸Rochester, New York, United States
Mayo Clinic in Florida
🇺🇸Jacksonville, Florida, United States
Kaiser Permanente-Santa Rosa
🇺🇸Santa Rosa, California, United States
Rocky Mountain Cancer Centers-Littleton
🇺🇸Littleton, Colorado, United States
Sutter Cancer Centers Radiation Oncology Services-Vacaville
🇺🇸Vacaville, California, United States
CentraState Medical Center
🇺🇸Freehold, New Jersey, United States