Comparative Evaluation of effect of Various Transdermal Patches and Oral NSAID on Post-Operative Endodontic Pain and Quality of Life - A Randomized Controlled Trial

Post-operative pain occurs only in 25-40 % patients and can last up to several days, depending upon peripheral and central mechanisms of hyperalgesia. Pulpal inflammation and necrosis with the corresponding peri radicular tissue changes cause the release of inflammatory mediators, including prostaglandins which are involved in pain medication. The rationale for the pharmacological management of post-endodontic pain is focused on the reduction of chemical inflammatory mediators that activate or sensitize peripheral nociceptors and the subsequent events involved in pain perception. Prostaglandin suppression is important as it lowers the pain threshold (i.e. allodynia) and sensitizes nociceptors to other pain mediators. Ibuprofen is the most frequently used NSAID for control of pain associated with root canal treatment. This trial will compare the efficacy of transdermal and oral analgesic delivery systems in managing post-operative endodontic pain.