NCT03939338Unknown不适用
Combination With Regulatory T Cell Levels and Cardiac Magnetic Resonance Imaging (CMR) to Assess the Severity and Prognosis of Reperfusion Injury After Primary PCI in STEMI Patients (TregCMRRS)
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- MACE (major adverse cardiovascular events)
研究概览
简要总结
This study aims to determine whether combination with regulatory T cell (Treg) levels and cardiac magnetic resonance imaging (CMR) are predictive of the severity of reperfusion injury following myocardial infarction and the prognosis in STEMI patients receiving primary percutaneous coronary intervention (PPCI).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed STEMI diagnosis
- •Undergoing primary percutaneous coronary intervention (presenting <12 hours after symptom onset)
- •Patients were able to complete cardiac magnetic resonance imaging (CMR) and speckle tracking imaging echocardiogram (STE) examinations
- •Patients agreed and provided informed consent
排除标准
- •Previous myocardial infarction or revascularization (PCI or CABG)
- •Congestive heart failure with LVEF<40%
- •Atrial fibrillation
- •Renal insufficiency (GFR < 30 ml/min/1.73m^2)
- •Acute infectious diseases within nearly 3 months
- •Rheumatic immune system diseases
- •Malignant tumors
- •Claustrophobia
- •Contraindicated to CMR
- •Patients do not agree to be included in the study
结局指标
主要结局
MACE (major adverse cardiovascular events)
时间窗: 12 months
nonfatal or fatal myocardial infarction, revascularization, cardiac death, nonfatal or fatal stroke, all cause of death
次要结局
- adverse cardiac remodeling(6 months)
研究者
Hongwei Li, MD
Prof.
Beijing Friendship Hospital
研究点 (1)
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