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Clinical Trials/CTRI/2026/01/101554
CTRI/2026/01/101554Not yet recruitingNot Applicable

Comparison of perioperative Dexamethasone split between two doses versus preoperative single dose for postoperative nausea and vomiting in Laparoscopic Gynecological Surgeries: A prospective randomized double-blind trial

Dr Ananta Srilalita Bulusu1 site in 1 country130 target enrollmentStarted: January 27, 2026Last updated:
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Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Sponsor
Enrollment
130
Locations
1
Primary Endpoint
TO COMPARE THE EFFECTS OF SPLIT DOSE OF DEXAMETHASONE GIVEN PREOPERATIVELY AND POSTOPERATIVELY VERSUS SINGLE DOSE OF DEXAMETHASONE GIVEN PREOPERATIVELY ON POSTOPERATIVE NAUSEA AND VOMITING IN PATIENTS POSTED FOR LAPAROSCOPIC GYNAECOLOGIACAL SURGERIES LASTING 2-3 HOURS
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Postoperative nausea and vomiting is common in laparoscopic gynaecologial surgeries. The purpose of the study to compare the effects of dexamethasone split dose ,i.e 4mg at the time of induction and 4mg after extubation  versus single dose i.e 8mg of Dexamethasone at the time of induction.

Study Design

Study Type
Interventional
Allocation
Randomized
Masking
Participant and Investigator Blinded

Eligibility Criteria

Ages
18.00 Year(s) to 60.00 Year(s) (—)
Sex
Female

Inclusion Criteria

  • •ASA CLASS 1 AND 2.

Exclusion Criteria

  • •1.PATIENTS WHO REFUSE TO GIVE CONSENT 2.PATIENTS WHO HAVE HISTORY OF ALLERGY TO DEXAMETHASONE 3.PREGNANT PATIENTS 4.PATIENTS WITH DIABETES MELLITUS 5.RHEUMATOID IMMUNE SYSTEM DISEASES 6.LIVER AND KIDNEY FAILURE.

Outcomes

Primary Outcomes

TO COMPARE THE EFFECTS OF SPLIT DOSE OF DEXAMETHASONE GIVEN PREOPERATIVELY AND POSTOPERATIVELY VERSUS SINGLE DOSE OF DEXAMETHASONE GIVEN PREOPERATIVELY ON POSTOPERATIVE NAUSEA AND VOMITING IN PATIENTS POSTED FOR LAPAROSCOPIC GYNAECOLOGIACAL SURGERIES LASTING 2-3 HOURS

Time Frame: TO ASSESS POSTOPERATIVE NAUSEA VOMITING AT 0, 6, 12, 18, 24, 48, 72 HOURS

Secondary Outcomes

  • effect of dexamethasone on blood sugar levels(24 hours after the surgery)

Investigators

Sponsor
Dr Ananta Srilalita Bulusu
Sponsor Class
Government medical college
Responsible Party
Principal Investigator
Principal Investigator

Ananta Srilalita Bulusu

Karnataka medical college and research institute

Study Sites (1)

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TO COMPARE THE EFFECTS OF SPLIT DOSE OF... | Clinical Trial