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临床试验/NCT07232173
NCT07232173已完成不适用

Comparative Study Between Pericapsular Nerve Group Block (PENG) Versus Suprainguinal Fascia Iliaca Compartment Block (SFIC) in Perioperative Hip Surgery

Ain Shams University1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2023年1月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
100
试验地点
1
主要终点
onset of analgesia

研究概览

简要总结

The hip joint is the largest and one of the most stable joints in the human body. It bears the majority of the body's weight during both dynamic and static activities, making it highly susceptible to degenerative diseases, particularly in the elderly population. In advanced cases, total hip arthroplasty (THA) is often required-currently ranking as the second most common joint replacement procedure worldwide.

Despite its clinical success, it is estimated that 7-28% of patients experience chronic postoperative pain following THA. This persistent pain significantly impairs quality of life and is receiving growing attention from healthcare professionals. Evidence suggests that unmanaged acute surgical pain is a major risk factor for the development of chronic postoperative pain, underscoring the importance of effective perioperative analgesia. Given the adverse effects associated with opioids, regional anesthesia techniques are increasingly favored for pain management.

Among these, the fascia iliaca compartment block (FICB) has been widely used to reduce postoperative pain intensity, although it carries potential drawbacks such as motor weakness or a need for supplemental opioid use. Recent anatomical studies by Short et al. have identified the anterior capsule of the hip joint as being innervated by the pericapsular nerve group (PNG) including the obturator nerve, accessory obturator nerve, and femoral nerve. The anatomical accessibility of these nerves has enabled the development of the pericapsular nerve group (PENG) block, a motor-sparing regional anesthesia technique that offers targeted analgesia by delivering local anesthetics into the myofascial plane between the psoas muscle and the superior pubic ramus.

While both FICB and PENG blocks are widely used in total hip replacement surgeries, comparative evidence evaluating their efficacy remains limited. Therefore, this study aims to compare the analgesic effectiveness of FICB and PENG blocks during the preoperative and postoperative phases of total hip arthroplasty.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Supportive Care
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
40 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •40 years or older
  • •non-pathologic hip fractures
  • •underwent total hip arthroplasty (THA) or hemiarthroplasty at Ain Shams University Hospitals
  • •physical status I, II and III according to the American Society of Anesthesiologists (ASA) classification.

排除标准

  • •pathological fracture
  • •allergy to study drugs.
  • •ASA IV (a patient with severe systemic disease that is a constant threat to life)
  • •bleeding tendencies
  • •dementia or any mental disability
  • •having sepsis

研究组 & 干预措施

ultrasound-guided supra-inguinal fascia iliaca block SFIC

Active Comparator

干预措施: Suprainguinal Fascia Iliaca compartment Block (SIFIC) (Procedure)

ultrasound-guided pericapsular nerve group block PENG

Active Comparator

干预措施: Pericapsular Nerve Group Block (PENG) (Procedure)

结局指标

主要结局

onset of analgesia

时间窗: Assessed before the block and every 3 minutes from blocking for 30 minutes afterwards.

defined as an NRS of 3 or less at rest and during passive 20° limb elevation.

次要结局

  • NRS over 24 hours(24 hours)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mohamed Noser

Dr

Ain Shams University

研究点 (1)

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