Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study
试验速览
- 阶段
- 不适用
- 入组人数
- 1,937,360
- 试验地点
- 1
- 主要终点
- Hazard ratios for the associations between social deprivation and initial presentation of 12 cardiovascular diseases.
研究概览
简要总结
Study of heterogeneity in associations between social deprivation and the initial presentation of 12 cardiovascular diseases.
详细描述
This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •One year prior to study entry (up-to-standard follow-up, CPRD quality research standard).
- •30 years or older
- •Recorded sex
- •Free of symptomatic CVD at inclusion.
排除标准
- •Pregnant women in the 6 months before the eligibility date
结局指标
主要结局
Hazard ratios for the associations between social deprivation and initial presentation of 12 cardiovascular diseases.
时间窗: Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years
Associations studied: * overall * by sex * by age group * in high risk groups (smokers, hypertensive disease, obese, diabetic, depression) * before and after the introduction of the Quality and Outcomes Framework in England
次要结局
- Lifetime cumulative incidence per quintile of social deprivation(Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years)
研究者
Harry Hemingway
Professor
University College, London