Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study

• Conditions: Abdominal Aortic Aneurysm; Coronary Heart Disease NOS; Unheralded Corronary Death; Intracerebral Haemorrhage; Heart Failure; Ischemic Stroke; Myocardial Infarction; Stroke; Peripheral Arterial Disease; Stable Angina Pectoris
• Interventions: Other: No treatment

• Registration Number: NCT01937065
• Lead Sponsor: University College, London

Brief Summary

Study of heterogeneity in associations between social deprivation and the initial presentation of 12 cardiovascular diseases.

Detailed Description

This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2013-07-02
• Status Verified: 2013-09
• Study First Submitted QC: 2013-09-03
• Last Update Submitted: 2013-09-03
• Study First Posted: 2013-09-09
• Last Update Posted: 2013-09-09
• Primary Completion: 2013-12
• Study Completion: 2014-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1937360

Inclusion Criteria

• One year prior to study entry (up-to-standard follow-up, CPRD quality research standard).
• 30 years or older
• Recorded sex
• Free of symptomatic CVD at inclusion.

Exclusion Criteria

• Pregnant women in the 6 months before the eligibility date

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
No treatment	No treatment	-

Primary Outcome Measures

Name	Time	Method
Hazard ratios for the associations between social deprivation and initial presentation of 12 cardiovascular diseases.	Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years	Associations studied: * overall; * by sex; * by age group; * in high risk groups (smokers, hypertensive disease, obese, diabetic, depression); * before and after the introduction of the Quality and Outcomes Framework in England

Secondary Outcome Measures

Name	Time	Method
Lifetime cumulative incidence per quintile of social deprivation	Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years

Trial Locations

Locations (1)

University College London; 🇬🇧 London, United Kingdom