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临床试验/NCT07303829
NCT07303829尚未招募不适用

Laproscopic Managment of Pyogenic Liver Abscess

Assiut University0 个研究点目标入组 30 人开始时间: 2026年1月1日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
30
主要终点
Major complication rate

研究概览

简要总结

Assess the efficacy and safety of laparoscopic management of liver abscess in achieving complete drainage and clinical recovery compared to conventional open or percutaneous methods, and to:

  1. To evaluate postoperative complications and recurrence rates.
  2. To compare hospital stay, recovery time, and overall morbidity.
  3. To determine patient outcomes and cost-effectiveness of laparoscopic intervention.

详细描述

Liver abscess is a localized collection of pus within the liver parenchyma, most commonly resulting from bacterial or amoebic infection. It remains a serious clinical condition requiring timely diagnosis and effective management to prevent complications such as sepsis or rupture. Traditionally, open surgical drainage was the standard treatment for complicated or multiloculated abscesses and in cases where percutaneous drainage failed. However, advances in minimally invasive surgery have introduced laparoscopic drainage as a safer and more efficient alternative.

Laparoscopic management offers several advantages, including smaller incisions, reduced postoperative pain, shorter hospital stays, and faster recovery compared to open surgery. Moreover, it allows direct visualization of the abscess cavity, facilitates breaking of loculations, debridement of necrotic tissue, and precise placement of drainage catheters. These features enhance the completeness of drainage and reduce recurrence rates.

Recent studies have demonstrated the efficacy of laparoscopic drainage, particularly in large, complex, or multiloculated liver abscesses where percutaneous methods are unsuccessful or contraindicated. A meta-analysis of 17 studies involving 608 patients reported a recurrence rate of only 4.22% with no procedure-related mortality in the laparoscopic group. Consequently, laparoscopic drainage is now considered a step-up approach in the management algorithm of liver abscess, bridging the gap between percutaneous and open surgical techniques, while ensuring optimal clinical outcomes and reduced morbidity.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adults ≥18 years.
  • Radiologically confirmed liver abscess (US/CT/MRI).
  • Abscess requiring drainage ≥5 cm,
  • Failed or contraindicated percutaneous drainage.
  • Recurrence after percutaneous drainage.

排除标准

  • Adults ≥18 years.
  • Radiologically confirmed liver abscess (US/CT/MRI).
  • Abscess requiring drainage ≥5 cm,
  • Failed or contraindicated percutaneous drainage.
  • Recurrence after percutaneous drainage.

结局指标

主要结局

Major complication rate

时间窗: 30 days

Procedure-related complications (Clavien-Dindo ≥ III) within 30 days.

Abscess recurrence

时间窗: 6 months.

Recurrence at the same or new site

次要结局

  • Technical success(30days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ebram Nashat Bastawroos Zakaria

Doctor

Assiut University

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