The aetiology of nocturnal symptoms in carpal tunnel syndrome

Conditions: carpal tunnel syndrome
10034606
compression neuropathy of the median nerve
nerve entrapment in the wrist

Registration Number: NL-OMON42718

Lead Sponsor: eurologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

• Electrophysiologically proven CTS
• History of nocturnal complaints of CTS leading to awakening >= two times per night
• Age >= 18 years
• Ability to provide informed consent

Exclusion Criteria

• Working night shifts during the study period
• Any skin condition of the hand that would make wearing of the Leiden Wrist Goniometer (LWG) uncomfortable.
• The need for immediate surgery or other treatment for CTS
• Any reason patients can not wear an ABPM on the contralateral arm, such as previous brachial lymphadenectomy

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Hypothesis 1: There is a specific position of the wrist causing nocturnal<br /><br>symptoms. 1a.) This position is the same in all patients. Parameter: The<br /><br>average angle of the wrist 15 minutes before every awakening compared to the<br /><br>average angle of the wrist during 15 minutes at the same time in another night<br /><br>in which the patient did not awake at that time.<br /><br><br /><br>Hypothesis 2: Nocturnal symptoms of CTS are related to a prolonged position of<br /><br>the wrist. Parameter: variance in position of the wrist during the 60 minutes<br /><br>prior to awakening compared with to variance in position during the same 60<br /><br>minutes in another night in which the patient did not awake at that<br /><br>time.<br /><br><br /><br></p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Hypothesis 3: Nocturnal symptoms of CTS are related to nocturnal drop in<br /><br>systemic BP. Parameter: BP preceding nocturnal symptoms compared to BP on a<br /><br>random chosen moment in that night in which the patient did not awake.<br /><br><br /><br>Hypothesis 4: Splinting of the wrist in neutral position results in a decrease<br /><br>of the frequency of nocturnal symptoms of CTS of at least 50%. Parameter:<br /><br>average frequency of awakenings during the first week compared to the second<br /><br>week. </p><br>