Survival Prediction in HNSCC Based on Gene Expression Profiles From FFPE Tissues
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 主要终点
- Identification of gene expression profiles used to predict survival as assessed by DNA microarray analysis
研究概览
简要总结
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict survival of patients with head and neck cancer.
PURPOSE: This laboratory study is assessing gene expression profiles in predicting survival of patients with head and neck cancer.
详细描述
OBJECTIVES:
- Identify gene expression profiles associated with survival by DNA microarray assay analysis using RNA from formalin-fixed paraffin-embedded tissue samples from patients with squamous cell carcinoma of the head and neck treated on clinical trial RTOG-9501.
OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed by DNA microarray analysis for gene expression profiling.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of squamous cell carcinoma of the head and neck, including 1 of the following sites:
- •Hypopharynx
- •Oral cavity
- •Oropharynx
- •Stage II-IV disease
- •Must have received treatment on clinical trial RTOG-9501
- •Formalin-fixed paraffin-embedded tissue samples available
排除标准
- •Not specified
- •PRIOR CONCURRENT THERAPY:
- •Not specified
结局指标
主要结局
Identification of gene expression profiles used to predict survival as assessed by DNA microarray analysis
时间窗: at time of surgical resection
次要结局
未报告次要终点
研究者
Barbara Murphy, MD
Professor of Medicine; Director, Cancer Supportive Care Program; Director, Head and Neck Research Program; Medical Oncologist
Vanderbilt-Ingram Cancer Center