Preventing Myocardial Ischemia by Preconditioning in Elective Operation for Abdominal Aortic Aneurysm

Phase 1

• Conditions: Aortic Aneurysm
• Interventions: Procedure: Normal surgery, with sham intervention without inflating arm cuff; Procedure: preconditioning

• Registration Number: NCT01523262
• Lead Sponsor: Aarhus University Hospital

Brief Summary

Primary To investigate whether peripheral predonditioning induced by brief, intermittent constriction of blood supply to an arm can reduce the incidence of perioperative myocardial ischemia in patients operated electively for infrarenal aortic aneurysm.

Secondary To investigate the impact of peripheral preconditioning on perioperative inflammatory response.

To investigate whether peripheral preconditoning can protect against perioperative myocardial infarction and reduced cardiac pump function.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2012-01-30
• Study First Submitted QC: 2012-01-31
• Study First Posted: 2012-02-01
• Status Verified: 2015-01
• Primary Completion: 2015-01
• Last Update Submitted: 2015-01-12
• Last Update Posted: 2015-01-14
• Study Completion: 2016-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• All patients older than 18 years, hospitalized for elective surgery of abdominal aortic aneurysm

Exclusion Criteria

• Lack of informed consent.
• Hemiparetic patient.
• Pregnancy or nursing patient.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
normal treatment	Normal surgery, with sham intervention without inflating arm cuff	Standard treatment
Preconditioning and normal treatment	preconditioning	-

Primary Outcome Measures

Name	Time	Method
measurements of CKMB and Troponin T	30 days

Trial Locations

Locations (2)

Aarhus University Hospital, Skejby; 🇩🇰 Aarhus, Aarhus N, Denmark

Aalborg Hospital; 🇩🇰 Aalborg, Denmark