Prospective, European collaborative multicenter observational study of standardized, ontogenetically based radical surgery in endometrial cancer FIGO IAG3 and stage IB to III by peritoneal mesometrial resection and therapeutic lymphadenectomy (PMMR/tLNE) without additional radiotherapy - PMMR-Study

niversitätsklinikum Essen0 个研究点目标入组 500 人开始时间: 2019年7月1日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Histologically proven endometrial carcinoma: endometroid and non-endometroid FIGO stages I-III; Karnofsky-Index = 70; unrestricted operability; Age >=18 years.
•- Completed treatment with according Cohort A, PMMR/targeted compartmental pelvic/paraaortic +/- complete pelvic and paraaortic LNE without adjuvant radiotherapy by the responsible clinic (clinician).
•- Completed treatment according Cohort B, current clinical practice including adjuvant treatment based on ESMO/ESGO/ESTRO guidelines [26] by the responsible clinic (clinician).
•- Informed consent of the patient

•Uterine pure sarcoma
•- Distant metastases; sclerodermia, lupus erythematodes, mixed connective tissue disease; secondary malignancy; previous radiotherapy of the pelvis.
•- Pregnancy
•- Patients with diseases of the connective tissue will be excluded because of unforeseeable (e.g. neurological) symptoms and disorders after surgery.
•- Postoperative radiotherapy could be administered with respect to the surgical field in R1 situation or if >= 5 lymph nodes were involved; in all other situations adjuvant radiotherapy will be an exclusion criterion for participation in the study cohort A.

发起方

niversitätsklinikum Essen