Cortisol profiles in the critically ill after traumatic brain injury

niversity of Bristol0 个研究点目标入组 30 人开始时间: 2019年9月4日最近更新: 2020年8月17日

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•Inclusion criteria for the TBI groups:
•1. Adults aged at least 18 years of age
•2. Intensive Care Unit admission
•3. Traumatic brain injury:
•3.1. 10 patients with moderate TBI (Glasgow Coma Score 9-12 after resuscitation or prior to intubation)
•3.2. 10 patients with severe TBI (Glasgow Coma Score =8 after resuscitation or prior to intubation)
•Inclusion criteria for the non-TBI group:
•1. Adults aged at least 18 years of age
•2. Bodily injuries sustained as a result of trauma but without significant head injury
•3. Intensive Care Unit admission

•Exclusion criteria for the TBI groups:
•1. Life or limb-threatening extra-cranial injury (in the opinion of the treating intensivist)
•2. Patients with known pre-existing HPA axis disease
•3. Untreated thyroid disease
•4. Current or prior steroid therapy within the last 3 months
•5. Patients less than 18 years of age
•6. Patients who are pregnant
•7. Prisoners
•8. Widespread burns/skin breakdown creating inability to place microdialysis catheter
•9. Admission with perceived devastating brain injury for purposes of prognostication or organ donation
•10. Refusal of consent or assent
•11. More than 48 hours after injury
•12. Severe metabolic acidosis (pH <7.20)
•Exclusion criteria for the non-TBI group:
•1. Significant head injury (GCS <13 or abnormal admission brain imaging)
•2. Patients with known pre-existing HPA axis disease
•3. Untreated thyroid disease
•4. Current or prior steroid therapy within the last 3 months
•5. Patients less than 18 years of age
•6. Patients who are pregnant
•7. Prisoners
•8. Widespread burns/skin breakdown creating inability to place microdialysis catheter
•9. Admission with devastating brain injury for purposes of prognostication or organ donation
•10. Refusal of consent or assent
•11. More than 48 hours after injury
•12. Severe metabolic acidosis (pH <7.20)

发起方

niversity of Bristol