ISRCTN37782238
Suspended
未知
Cortisol profiles in the critically ill after traumatic brain injury
niversity of Bristol0 sites30 target enrollmentSeptember 4, 2019
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Traumatic brain injury (TBI) - moderate and severe, major trauma without traumatic brain injury
- Sponsor
- niversity of Bristol
- Enrollment
- 30
- Status
- Suspended
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Inclusion criteria for the TBI groups:
- •1\. Adults aged at least 18 years of age
- •2\. Intensive Care Unit admission
- •3\. Traumatic brain injury:
- •3\.1\. 10 patients with moderate TBI (Glasgow Coma Score 9\-12 after resuscitation or prior to intubation)
- •3\.2\. 10 patients with severe TBI (Glasgow Coma Score \=8 after resuscitation or prior to intubation)
- •Inclusion criteria for the non\-TBI group:
- •1\. Adults aged at least 18 years of age
- •2\. Bodily injuries sustained as a result of trauma but without significant head injury
- •3\. Intensive Care Unit admission
Exclusion Criteria
- •Exclusion criteria for the TBI groups:
- •1\. Life or limb\-threatening extra\-cranial injury (in the opinion of the treating intensivist)
- •2\. Patients with known pre\-existing HPA axis disease
- •3\. Untreated thyroid disease
- •4\. Current or prior steroid therapy within the last 3 months
- •5\. Patients less than 18 years of age
- •6\. Patients who are pregnant
- •7\. Prisoners
- •8\. Widespread burns/skin breakdown creating inability to place microdialysis catheter
- •9\. Admission with perceived devastating brain injury for purposes of prognostication or organ donation
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
Cortisol Profiles in the Critically IllCritically ill patients following cardiac surgeryCirculatory SystemISRCTN11200968niversity of Bristol20
Completed
Not Applicable
Cortisol Levels as a Measure of Accumulated Physiological Stress in ICU Patients Undergoing Mechanical VentilationCritical IllnessNCT03736135Corporacion Parc Tauli26
Completed
Not Applicable
Corticosteroid level in victims after successful cardiac arrestDecrease in cortisol level after cardiac resuscitation.Other and unspecified adrenocortical insufficiencyIRCT201111092337N5Research center of Tehran University of Medical Sciences50
Not yet recruiting
Not Applicable
Thyroid and Cortisol Hormone Response to SepsisSepsisNCT06289179Assiut University114
Active, not recruiting
Not Applicable
Assessing Baseline Cortisol Levels in Patients Admitted With Septic Shock in Intensive Care UnitCritical IllnessAdrenal InsufficiencySeptic ShockNCT05741762Dr Adnan Agha50