Study on intestinal microecological environment and intervention effect of 'phlegm dampness constitution NAFLD' population based on metagenomics

Phase 1

Recruiting

• Conditions: onalcoholic fatty liver disease

• Registration Number: ITMCTR2100004286
• Lead Sponsor: The Second Affiliated Hospital of Shandong University of traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Patients aged 20-50 years old;
2. Patients who meet the criteria of mild constitution and phlegm dampness constitution respectively;
3. Patients who have lived in Jinan for more than one year and have not taken antibiotics and other drugs within one month;
4. Patients who have no major disease and have the ability to cooperate with the completion of this trial;
5. Phlegm dampness constitution NAFLD population should meet the following three conditions at the same time:
(1) There was no history of alcohol drinking or the equivalent alcohol consumption was less than 140g / week (female less than 70g / week);
(2) Except viral hepatitis, drug-induced liver disease, total parenteral nutrition, hepatolenticular degeneration, autoimmune liver disease and other specific diseases that can lead to fatty liver;
(3) The histological changes of liver biopsy were consistent with the pathological diagnostic criteria of fatty liver disease. In view of the difficulty in obtaining liver histological diagnosis, NAFLD was defined as:
No history of drinking;
The imaging findings of the liver were consistent with the diagnostic criteria of diffuse fatty liver, and there was no other reason to explain.

Exclusion Criteria

1. Patients taking various drugs or receiving other treatments;
2. Patients with other diseases such as severe hypertension and organic heart disease;
3. Pregnant, menstrual and lactating women.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
score of constitution;blood lipids;

Secondary Outcome Measures

Name	Time	Method
BMI;blood pressure;B-can;