The Anti-Inflammatory Effects of Exercise and Peanut Consumption

Not Applicable

Terminated

• Conditions: Peanut Consumption; High Intensity Aerobic Exercise

• Registration Number: NCT03212144
• Lead Sponsor: New York State Psychiatric Institute

Brief Summary

This study will enroll and randomly assign 30 sedentary, healthy overweight men and women to two groups. Participants will either start by consuming peanuts for 4 weeks, and then go on to exercise at high intensity intervals (HIIT) for 4 weeks, or the reverse order. The study will test and compare the effect of peanuts and exercise on inflammation and heart rate variability as indicators of heart health. Specifically, the study will measure inflammation in the blood because there is evidence that higher inflammation is found in heart disease patients. There is also evidence that inflammation is related to death as a result of heart disease in healthy individuals. Finally, there are ongoing trials targeting these markers to improve heart health. The study hypothesizes that peanuts and exercise will reduce inflammation. It is also expected to find less inflammation because exercise and peanut consumption activate a part of the nervous system that has been shown to cause a similar effect.

Additionally, previous studies show that inflammation involves the mitochondria in the cell, the part of the cell that produces energy. For this reason, it is expected that exercise and peanuts will cause changes in the mitochondria. The study will test and compare mitochondrial activity in response to peanut consumption and exercise.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-06-08
• Study First Submitted QC: 2017-07-06
• Study First Posted: 2017-07-11
• Study Start: 2017-08-20
• Primary Completion: 2018-12-31
• Results First Submitted: 2019-12-18
• Study Completion: 2019-12-31
• Status Verified: 2020-03
• Results First Submitted QC: 2020-03-24
• Last Update Submitted: 2020-03-24
• Results First Posted: 2020-04-06
• Last Update Posted: 2020-04-06

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Plasma Levels of Pro-inflammatory Cytokines (IL-6 and TNF-α)	at study entry	cytokines (IL-6 and TNF-α) will be collected from blood samples

Trial Locations

Locations (1)

Columbia University Medical Center; 🇺🇸 New York, New York, United States