Stress, Anxiety and Type A Personality and Analgesics. Impact on Induction Time and Consumption of Analgesics During Cardiac Surgery
Overview
- Phase
- Phase 4
- Intervention
- Sufentanil I
- Conditions
- Postoperative; Dysfunction Following Cardiac Surgery
- Sponsor
- Aarhus University Hospital
- Enrollment
- 60
- Primary Endpoint
- Association between preoperative personality/stress/anxiety and time (minutes) to reach anaesthetic depth goal by bi-spectral index (BIS)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Patients scheduled for elective cardiac surgery are preoperative evaluated using different personality type, stress and anxiety tests.
Patient are randomized to receive the investigators' standard moderate dose sufentanil (bolus 1microgram/kg and propofol 0.03 mg/kg/min) or low dose sufentanil (bolus 0.5 microgram/kg and propofol 0.06 mg/kg/min).
Detailed Description
Patients randomized and the type of induction informed to the anaesthetist 30 minutes before surgery. Patients are monitored before induction of anesthesia. Propofol is started on the randomized infusion rate. Sufentanil bolus are given according to randomization. BIS level is followed. Time to reach BIS \< 50 is monitored. BIS after 30, 60 and 90 minutes are registered. Lowest BIS during surgery are registered. Total amounts of sufentanil and propofol recorded.
Investigators
Carl-Johan Jakobsen
Consultant Anesthesiologist, Ass professor
Aarhus University Hospital
Eligibility Criteria
Inclusion Criteria
- •All elective cardiac surgery patients
Exclusion Criteria
- •Patients requiring special attention or monitoring during induction
- •Patients with expected longer postoperative ventilation time
- •Patients allergic to sufentanil and or propofol
- •Participation in other projects
- •Pregnancy
Arms & Interventions
Sufentanil I
Randomized arm "moderate" sufentanil I: bolus 1 microgram/kg propofol I: infusion 0.03 mg/kg/min
Intervention: Sufentanil I
Sufentanil I
Randomized arm "moderate" sufentanil I: bolus 1 microgram/kg propofol I: infusion 0.03 mg/kg/min
Intervention: Propofol I
Sufentanil II
Randomized arm "low" sufentanil II bolus 0.5 microgram/kg propofol II: infusion 0.06 mg/kg/min
Intervention: Sufentanil II
Sufentanil II
Randomized arm "low" sufentanil II bolus 0.5 microgram/kg propofol II: infusion 0.06 mg/kg/min
Intervention: Propofol II
Outcomes
Primary Outcomes
Association between preoperative personality/stress/anxiety and time (minutes) to reach anaesthetic depth goal by bi-spectral index (BIS)
Time Frame: Up to 30 minutes
Minutes to reach BIS 50
Potential of sufentanil regime on fast-track measured by ventilation time and association with eligible discharge from intensive care unit.
Time Frame: Up to 24 hours
Postoperative ventilation time (hours/minutes) and the association to eligible discharge from ICU.
Secondary Outcomes
- Association between preoperative personality/stress/anxiety tests and postoperative care using postoperative quality score(up to 24 hours)
- Association between preoperative personality/stress/anxiety and total amounts of sufentanil and propofol(Up to 12 hours)
- Sufentanil regime and association to haemodynamic parameters (blood pressures, heart rate, cardiac output, oxygenation)(up to 24 hours)