Cardiopulmonary Interactions in Patients With Heart Failure (Kardio-pulmonale Interaktionen Bei Patienten Mit Linksherzerkrankungen)
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Risk factors for a low DLCO
研究概览
简要总结
This study aims to evaluate cardiopulmonary interactions in patients with heat failure
详细描述
Heart failure is one of the most common diseases, especially in ageing populations, affecting ≥10% of persons 70 years of age or older. There is a growing body of evidence that dyspnea in patients with heart failure is not only related to low cardiac output and pulmonary venous congestion, but also to functional and structural alterations of the lungs.Pulmonary hypertension is a well-known complication of heart failure, but recent evidence suggests that the alveolo-capillary membrane is also affected, at least in subgroups of patients with heart failure.
Damage to the alveolo-capillary membrane is reflected by a low diffusion capacity of the lungs for carbon monoxide (DLCO).
In this study we aim to describe the alteration of lung function and obtain morphometric data of the capillary bed of patients with heart failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Risk factors for a low DLCO
时间窗: Baseline, Phone visit every 6 months up to 36 months
Obtain risk factors for a low DLCO
Predictors of survival and heart-failure related hospitalisations
时间窗: Baseline, 1 year, Phone visit every 6 months, up to 36 months
Predictors of survival and heart-failure related hospitalisations
Pulmonary Function in Heart failure
时间窗: Every Year up tp 36 months
Pulmonary Function including DLCO (diffusion capacity of the lungs for carbon monoxide)
Relationship DLCO and hemodynamics
时间窗: Every year up to 36 months, hemodynamics are not mandatory
To study the relationship between DLCO, KCO (diffusion capacity per unit alveolar volume) and hemodynamics in patients with heart failure
Impact of LVAD (left ventricular assist device) implantation on lung function
时间窗: LVAD implantation, 6 months after LVAD implantation, LVAD explantation, 6 months after LVAD explantation, and yearly up to 36 months
Impact of LVAD implantation on lung function
次要结局
- Morphometric data of the pulmonary capillary bed(Biopsies are taken once during LVAD implantation, Heart transplantation or LVAD explantation if performed (variable time points) and compared with the functional assessments, in particular with DLCO and KCO up to 36 months.)
研究者
Karen Olsson, PD Dr.
PD Dr. med. Karen Olsson
Hannover Medical School