Cardiac Biomarkers in Patients With Single Ventricle Physiology
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
All neonates with congenital heart disease undergoing stage one palliation (Norwood procedure, Damus-Kaye-Stansel procedure) at Texas Children's Hospital will be regularly monitored for B-type natriuretic peptide (BNP) and Troponin level before the surgical procedure, on arrival to the cardiac intensive care unit after their surgical procedure, every 6 hours during the first 24 hours of the post-operative period, followed by daily levels for the first week, and then weekly during patient's regular laboratory work up schedule.
These cardiac biomarkers are linked to demographic, hemodynamic, respiratory, pharmacological data available via Sickbay.
详细描述
All neonates with congenital heart disease undergoing stage one palliation (Norwood procedure, Damus-Kaye-Stansel procedure) at Texas Children's Hospital will be regularly monitored for B-type natriuretic peptide (BNP) and Troponin level before the surgical procedure, on arrival to the cardiac intensive care unit after their surgical procedure, every 6 hours during the first 24 hours of the post-operative period, followed by daily levels for the first week, and then weekly during patient's regular laboratory work up schedule.
These cardiac biomarkers are linked to demographic, hemodynamic, respiratory, pharmacological data available via Sickbay.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 2 Months（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of Hypoplastic Left Heart Syndrome as congenital heart disease as a neonate
排除标准
- •Other diagnosis of congenital heart disease than Hypoplastic Left Heart Syndrome Patients older than 30 days
结局指标
主要结局
Mortality
时间窗: 3- 6 months depending on second stage procedure
Mortality up to anticipated Glenn Procedure
次要结局
- NEC(3- 6 months depending on second stage procedure)
- Reintubation(3- 6 months depending on second stage procedure)
- Cath intervention(3- 6 months depending on second stage procedure)
研究者
Marc Anders
Assistant Professor
Baylor College of Medicine