Effects of Heart Rate Oscillations During Meditation on Plasma Biomarkers of Alzheimer's Disease
- Conditions
- Alzheimer Disease
- Interventions
- Behavioral: Belly-focus meditationBehavioral: Belly-focus meditation with slow breathing
- Registration Number
- NCT06210035
- Lead Sponsor
- University of Southern California
- Brief Summary
In the current study, we will examine how two types of concentration meditation practices affect plasma biomarkers of Alzheimer's Disease (AD). We will also examine the effects of the two types of meditation practices on emotional well-being and episodic memory. Healthy adults aged 18-35 who meet all eligibility criteria will be invited to this study. Participants will be asked to engage in one week of daily meditation practice or no-intervention control task at home. They will also be asked to visit the lab twice, once before and once after the intervention, to provide blood samples to assess plasma biomarkers of AD and to complete emotion questionnaires and a memory test.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 94
- Fluent in English
- Aged between 18-35 years old
- Agree to provide blood samples
- Healthy adults who weigh at least 110 pounds
- Agree to devote 40 minutes daily to this study for a week
- Have a disorder that would affect heart rhythm or function (e.g., abnormal cardiac rhythm, dyspnea, heart disease including coronary artery disease, angina and arrhythmia)
- Regularly practicing any relaxation, meditation or yoga that involve breathing focused practices lasting for more than an hour each week
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Belly-focus concentration meditation Belly-focus meditation Participants will engage in concentration meditation for 40 minutes every day for a week while recording heart rate. They will focus on the sensations around the belly. Belly-focus concentration meditation with slow breathing Belly-focus meditation with slow breathing Participants will engage in concentration meditation and slow breathing for 40 minutes every day for a week while recording heart rate. They will focus on the sensations around the belly while breathing slowly.
- Primary Outcome Measures
Name Time Method Change in plasma amyloid beta levels Measured from blood draws before and after a one-week intervention The investigators will compute an aggregate score based on both plasma Ab40 and Ab42 levels. The investigators will conduct a time (pre, post) X condition ANOVA to test for a time X condition interaction in plasma Ab levels (to assess group differences in change).
Change in plasma Ab42/40 ratio Measured from blood draws before and after a one-week intervention The investigators will conduct a time X condition ANOVA to test for a time X condition interaction with plasma Ab42/40 ratio scores as the dependent variable (to assess group differences in change).
- Secondary Outcome Measures
Name Time Method Change in emotional well-being Measured before and after a one-week intervention The investigators will conduct a time X condition ANOVA to test for a time X condition interaction with emotional well-being as the dependent variable (to assess group differences in change).
Change in plasma pTau-181/tau ratio Measured from blood draws before and after a one-week intervention The investigators will conduct a time X condition ANOVA to test for a time X condition interaction with plasma pTau-181/tau ratio as the dependent variable (to assess group differences in change).
Trial Locations
- Locations (1)
University of Southern California
🇺🇸Los Angeles, California, United States