Efficacy and safety of cream containing Centella asiatica extract for treatment of atopic dermatitis patients

Phase 2

Recruiting

• Conditions: skin rash, Atopic dermatitis; Atopic Dermatitis, Centella asiatica cream, SCORAD, eczema, Quality of life

• Registration Number: TCTR20190806006
• Lead Sponsor: Thammasat University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-08-06
• Study Completion: 2020-07-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1 Male and female
2 Age of 1-17 years old
3 Patients have been diagnosed as atopic dermatitis by pediatric doctor
4 Atopic dermatitis patients with mild to moderate severity (SCORAD score < 40)
5 Onset not more than 6 months
6 Willing to participate in the trial

Exclusion Criteria

1 History or presence of skin cancer of suspicious lesions
2 Participate in another study within the previous 4 weeks.
3 Allergy or sensitivity to CA or herbs in the family of Apiaceae
4 Applied any moisturizer on the skin lesions

Discontinuation criteria
1 Skin lesions flare-up in the volunteers (SCORAD score more than 40)
2 Secondary infection on-top to the skin
3 The occurrence of any severe adverse event
4 Applied any moisturizer on the skin lesions
5 Loss follow up more than 1 visit, or at the last week
6 Loss of follow up more than 1 appointment and at week 4
7 Do not desire to continue the trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the severity of Atopic dermatitis 4 weeks SCORAD Score

Secondary Outcome Measures

Name	Time	Method
Safety 4 weeks patient's interview, Naranjo algorithm ,Quality of life 4 weeks IDQOL/CDLQI