Moving Yourself in Space and Time Identifying Spatial and Temporal Components of Complex Rhythmic Movement Training for People With Parkinson's Disease and Cognitive Impairment

Emory University1 个研究点分布在 1 个国家目标入组 210 人开始时间: 2022年3月25日最近更新: 2026年7月13日

适应症

干预措施

试验速览

阶段: 不适用
状态: 招募中
发起方: Emory University
入组人数: 210
试验地点: 1
主要终点: Four-Square Step Test (FSST)

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study is being done to answer the question: Do people with Parkinson's benefit from a new stepping therapy, and how do people with Parkinson's best learn new steps and rhythms set to music? Researchers will also compare individuals with Parkinson's Disease with people with Mild Cognitive Impairment, and with people with neither of these conditions.

The purpose of this study is to identify principles of human-music interactions to establish underlying guiding theories for application to music-based rehabilitation for older populations with neurodegenerative disease, leading to more refined and targeted music-based rhythmic movement therapies.

详细描述

This study aims to analyze the effects of an innovative rehabilitation intervention comprising complex rhythmic movement sequence (CRMS) rehabilitation (aka, Spatiotemporal Activity Modification (STEAM)) training for adults. The central hypothesis is that the spatial and temporal components of CRMS are learned at slower rates in mild cognitive impairment (MCI) than in controls, and that CRMS-based rehabilitation strategies can improve cognitive and mobility status in MCI. Researchers hypothesize that people with cognitive impairment or Parkinson's disease (PD) will show reduced capacity and slower responses when modulating their movements to auditory cues encoded within complex musical-rhythmic patterns.

Musical rhythm, which includes the timing and pattern of sound in music, can be communicated through touch or via audible cues.

Objective 1: Evaluate the hypothesis that people with cognitive impairment or Parkinson's disease (PD) will show reduced capacity and slower responses when modulating their movements to auditory cues encoded within complex musical-rhythmic patterns.

Aim 1. Determine whether the temporal and spatial components of movement are learned at different timescales during human-music movement sequence learning.

Researchers will draw on research in music theory to develop a novel, task-specific set of musical patterns that map and facilitate learning of complex spatiotemporal rhythms during walking tasks. The research team will measure spatial, temporal, and kinematic variables during the physical human-music interaction and will alter combinations of spatial and temporal relationships within movements, in healthy younger (18-35 years), a subset of whom (n=10) are experienced dancers, and individuals (age older than 50 years), individuals with MCI, and individuals with PD. Researchers will analyze data from single-session time courses of learning rhythm, within-session changes, and short-term (24-hour) retention.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围: 18 Years 至 79 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•for Young adults and adults with normal cognition (NC):
•18 to 35 Years old
•Montreal Cognitive Assessment (MoCA) score of 26 to 30
•Inclusion Criteria for Older Adults:
•50 to 79 with or without MCI
•50 to 79 years old with Parkinson's disease (PD), who do NOT have impaired decision-making capacity
•Participants who achieve less than 150 minutes moderate or 75 minutes vigorous aerobic activity per week (as per the US Department of Health and Human Services (HHS)),

排除标准

•for all groups:
•Acute medical illness requiring hospitalization;
•Uncontrolled congestive heart failure;
•History of stroke in the past three years;
•Inability to perform study procedures;
•Medical or physical conditions that would preclude participation (e.g., severe arthritis or mobility problems, uncontrolled hypertension or diabetes, renal failure, history of angina with activity);
•On medications that could adversely affect cognition, e.g., antipsychotics, opioids, stimulants, chemotherapy, and neurologic prescriptions to treat Multiple Sclerosis. When applicable, enrollment will be delayed until dosages are stable on e.g., Aricept, Namenda, anticholinesterase inhibitors, for at least 3 months
•Psychotic disorders
•Confounding neurologic conditions [e.g., active central nervous system (CNS) opportunistic infections, seizure disorders, head injury with loss of consciousness >30 minutes, intracranial neoplasms, stroke with neurological or neuropsychiatric sequelae]
•Substance Use Disorder, Major Depressive Disorder, and Generalized Anxiety Disorder within six months of evaluation.
•Inability to provide informed consent

研究组 & 干预措施

Young adults and adults with normal cognition (NC)

Active Comparator

Participants will attend daily (3-5 times/week) lessons that will last 1.5h for a month (e.g., 3-5 weeks) and will receive contact and monitoring from study staff. The Principal Investigator will monitor fidelity via weekly reports from interventionists.

干预措施: Complex Rhythmic Movement Sequences (CRMS) Sessions (Other)

Older adults with MCI

Experimental

干预措施: Complex Rhythmic Movement Sequences (CRMS) Sessions (Other)

Older adults without MCI

Active Comparator

干预措施: Complex Rhythmic Movement Sequences (CRMS) Sessions (Other)

Older adults with PD

Experimental

Participants will attend daily (3-5 times/week) lessons that will last 1.5 h for a month (e.g., 3-5 weeks) and will receive contact and monitoring from study staff. The Principal Investigator will monitor fidelity via weekly reports from interventionists.

干预措施: Complex Rhythmic Movement Sequences (CRMS) Sessions (Other)