A comprehensive assessment of coronary physiology in cardiogenic shock.

Not Applicable

• Conditions: Cardiogenic shock; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12621001263886
• Lead Sponsor: Alfred Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-09-17
• Last Update Posted: 27 September 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

1. Ages of 18 and above.
2. Coronary angiography being undertaken as part of routine patient care as determined by the treating team.
3. SCAI Shock stage C or less
4.Onset of symptoms <24 hours prior.
5.Measurements to be performed at time of coronary angiography

Exclusion Criteria

•Pregnant and breastfeeding women, due to the radiation exposure inherent to this study
•Non-cardiac cause of shock (e.g. pulmonary embolism, pneumothorax, cardiac tamponade, etc.)
•Active bleeding
•Prior coronary artery bypass grafting
•Mechanical complication of surgery
•Known left ventricular thrombus
•Mechanical aortic valve
•Patients with contraindications to adenosine including: asthma/bronchospasm, greater than first degree heart block or sick sinus syndrome without a pacemaker, symptomatic aortic stenosis or hypertrophic cardiomyopathy, cerebral ischaemia or current dipyridamole medication use.
•Considered prohibitively hemodynamically unstable (e.g. Noradrenaline dose>50mcg/min)
•Prolonged cardiac arrest (in or out-of-hospital) > 20 minutes prior to return of spontaneous circulation
•Death is considered imminent

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Index of microcirculatory resistance (IMR) using an angioplasty wire. [At the time of physiology measurements being obtained];Fractional flow reserve (FFR) using an angioplasty wire. [At time of index coronary angiogram ];Coronary flow reserve (CFR) using an angioplasty wire. <br>[At time of index angiogram]

Secondary Outcome Measures

Name	Time	Method
Change in coronary perfusion with haemodynamic support ramping.[At the time of coronary physiology assessment. The will be determined using a coronary pressure wire and the Coroventis/Coroflow system. ]