Efficacy of inhaled rhDNase for acute asthma in childhood.
Completed
- Conditions
- acute childhood asthma
- Registration Number
- NL-OMON29109
- Lead Sponsor
- Erasmus MC, Sophia Children's Hospital
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Children, aged 2-18 years, with acute asthma who require at least two doses of bronchodilators at the emergency department.
Exclusion Criteria
1. Dyspnoea due to other causes than asthma;
2. Patients with a concurrent chronic pulmonary disease, such as CF, BPD;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement in asthma score 1 hour after intervention.
- Secondary Outcome Measures
Name Time Method 1. Need for hospital admission;<br /><br>2. Duration of hosptial admission;<br /><br>3. Asthma score at 2,6,12 and 24 hours after intervention;<br /><br>4. Heart rate, respiratory rate and oxygen saturation;<br /> <br>5. Need for additional oxygen;<br /><br>6. Number of bronchodilators;<br /><br>7. Doctor’s visit or readmission and use of rescue bronchodilator aerosol therapy following 72 hours after discharge from EMD;<br /><br>8. Cost-consequence analysis.